Evidence map›Paper›PMID 35536780›Full record

ArticlePloS one2022

Experimental evaluation of a metofluthrin passive emanator against Aedes albopictus.

Olivia Zarella, Uche Ekwomadu, Yamila Romer, Oscar D Kirstein, Azael Che-Mendoza, Gabriela González-Olvera, Pablo Manrique-Saide, Gregor Devine, Gonzalo M Vazquez-Prokopec

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Olivia ZarellaDepartment of Environmental Sciences, Emory University, Atlanta, GA, United States of America.
Uche EkwomaduDepartment of Environmental Sciences, Emory University, Atlanta, GA, United States of America.
Yamila RomerDepartment of Environmental Sciences, Emory University, Atlanta, GA, United States of America.
Oscar D KirsteinDepartment of Environmental Sciences, Emory University, Atlanta, GA, United States of America.
Azael Che-MendozaUnidad Colaborativa de Bioensayos Entomológicos, Campus de Ciencias, Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.
Gabriela González-OlveraUnidad Colaborativa de Bioensayos Entomológicos, Campus de Ciencias, Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.
Pablo Manrique-SaideUnidad Colaborativa de Bioensayos Entomológicos, Campus de Ciencias, Biológicas y Agropecuarias, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.
Gregor DevineMosquito Control Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Gonzalo M Vazquez-ProkopecDepartment of Environmental Sciences, Emory University, Atlanta, GA, United States of America.ORCID 0000-0002-0710-270X
Emory University · USAutonomous University of Yucatán · MXQIMR Berghofer Medical Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith the recent occurrence of locally transmitted Aedes-borne viruses in the continental United States and Europe, and a lack of effective vaccines, new approaches to control Aedes aegypti and Aedes albopictus are needed. In sub-tropical urban settings in the US, Ae. albopictus is a dominant nuisance and arbovirus vector species. Unfortunately, the vector control toolbox against Ae. albopictus is not as well developed as for Ae. aegypti. Here, we evaluate the efficacy, longevity, and range of protectiveness of a novel passive metofluthrin emanator (10% active ingredient in a polyethylene mesh) against Ae. albopictus indoors and outdoors.

methodsFour studies were conducted comparing the presence of the metofluthrin emanator to a control lacking emanator with interest in quantifying efficacy by human landing counts. Studies evaluated the effect of an emanator at varying distances from one or more human volunteers indoors and outdoors. Efficacy of emanators over time since activation was also evaluated.

resultsMixed-effects models determined that sitting in close proximity to an emanator reduced landings by 89.5% outdoors and by 74.6% indoors. The emanator was determined protective when located immediately next to a human volunteer outdoors but not uniformly protective when located further away. The emanator was protective at all tested distances from the device indoors. Mortality of mosquitoes exposed to metofluthrin emanators was ~2x higher than those who were not exposed in indoor conditions. Finally, a Generalized Additive Model determined that emanators used continuously outdoors lost their effect after 2.5 weeks and stopped inducing paralysis in mosquitoes after 3.8 weeks of use.

conclusionsWe show strong and lasting efficacy of 10% metofluthrin emanators against field Ae. albopictus both in indoor and outdoor conditions. Metofluthrin emanators can protect people from Ae. albopictus bites, representing a viable option for reducing human-mosquito contacts at home and beyond.

Indexed as

AedesInsecticidesAnimalsCyclopropanesFluorobenzenesHumansMosquito ControlMosquito Vectors(2,3,5,6-tetrafluoro-4-methoxymethylphenyl)methyl-2,2-dimethyl-3-(1-propenyl)cyclopropanecarboxylateCyclopropanesFluorobenzenesInsecticides

Identifiers

PMID35536780
PMCPMC9089854
OpenAlexW4229454070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.