ArticleJournal of applied clinical medical physics2022
Novel approach to semi-quantification of tracer accumulation in dopamine transporter scan.
Article in Journal of applied clinical medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Critical review of partial volume correction methods in PET and SPECT imaging: benefits, pitfalls, challenges, and future outlook.European journal of nuclear medicine and molecular imaging · 2026Review
- Novel approach to semi-quantification of tracer accumulation in dopamine transporter scan.Journal of applied clinical medical physics · 2022Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAccurate tracer accumulation evaluation is difficult owing to the partial volume effect (PVE). We proposed a novel semi-quantitative approach for measuring the accumulation amount by examining the approximate image. Using a striatal phantom, we verified the validity of a newly proposed method to accurately evaluate the tracer accumulations in the caudate and putamen separately. Moreover, we compared the proposed method with the conventional methods.
methodsThe left and right caudate/putamen regions and the whole brain region as background were identified in computed tomography (CT) images obtained by single-photon emission computed tomography (SPECT)/CT and acquired the positional information of each region. SPECT-like images were generated by assigning assumed accumulation amounts to each region. The SPECT-like image, approximated to the actual measured SPECT image, was examined by changing the assumed accumulation amounts assigned to each region. When the generated SPECT-like image most approximated the actual measured SPECT image, the accumulation amounts assumed were determined as the accumulation amounts in each region. We evaluated the correlation between the count density calculated by the proposed method and the actual count density of the
resultsThe correlation coefficients between the actual count density and the SPECT count densities were 0.997, 0.973, 0.951, 0.950, and 0.996 for the proposed method, CT-guide method, GTM method, RBV method, and Southampton method, respectively. The correlation of the proposed method was significantly higher than those of the other methods.
conclusionsThe proposed method could calculate accurate accumulation amounts in the caudate and putamen separately, considering the PVE.
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