ArticleAmerican journal of respiratory and critical care medicine2022
Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage Chronic Obstructive Pulmonary Disease.
Erratum issued Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT01969344 (Subpopulations and Intermediate Outcome Measures in COPD Study), which is not on this map. Cited by 64 papers.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Subpopulations and Intermediate Outcome Measures in COPD Study
Who cites it
64 citing papers in PubMed, 89 citations in OpenAlex.
- Review
- Review
- The redefined identity ofJournal of bacteriology · 2026Review
- Dynamic balance of the lung microbiome in health and respiratory diseases.Chinese medical journal · 2026Review
- The Gut-Lung Microbiome Axis in Alveolar Stem Cell Regeneration and Lung Repair.Microorganisms · 2026Review
- Lung Microbiome Diversity, Infection Dynamics, and Microbe-Mediated Cross-Protection.MicrobiologyOpen · 2026Review
- Epoxyeicosatrienoic acids protect airway epithelial mitochondria by activating the cAMP/PKA-DRP1 Ser637 axis in cigarette smoke-induced lung injury.Respiratory research · 2026Article
- Extracellular Matrix-Derived Matrikines: Circulating Peptides as Candidate Mediators of Lung-to-Brain Signaling.International journal of molecular sciences · 2026Review
- Sex-Specific Plasma Metabolomic Signatures in COPD Reveal Creatine, Purine/Urate, and Bile-Acid Axes.Metabolites · 2026Article
- Neutrophil-to-lymphocyte ratio in amyotrophic lateral sclerosis: a systematic review and meta-analysis.Brain communications · 2026Review
- Why the COPD Microbiome Matters: How Airway Microbes Shape Disease Severity and Treatment Response.International journal of chronic obstructive pulmonary disease · 2026Review
- Gut-Lung Microbiota Axis Shapes the Immune Microenvironment and Immunotherapeutic Response in Lung Cancer.International journal of biological sciences · 2026Review
- Multi-omics to study chronic respiratory diseases and viral infections.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Effects of Inhaled Corticosteroids/Long-Acting Beta-Agonists (ICS/LABA) on Airway Microbial Diversity and IL-8/IL-10 Cytokine Levels in Stable COPD.Combinatorial chemistry & high throughput screening · 2026Article
- [Research Progress on the Regulatory Mechanism of Respiratory Microbiota in the Comorbidity of Chronic Obstructive Pulmonary Disease and Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025Review
- Epigenomic study of the lower airway reveals COPD-associated methylation patterns and potential microbiota links.BMJ open respiratory research · 2025Article
- Integrated multi-omics profiling for risk stratification in Asians with COPD.Respiratory research · 2025Article
- Association between multimarkers of metabolic malnutrition and inflammation and risk of chronic obstructive pulmonary disease and lung function: a prospective cohort study of UK biobank.Nutrition & metabolism · 2025Article
- Article
- Extracellular iron and the lung microbiome in smoking and COPD.ERJ open research · 2025Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
28 authors at 15 institutions in 2 countries.
Siddharth S MadapoosiDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Charmion Cruickshank-QuinnDepartment of Pharmaceutical Sciences, University of Colorado, Anschutz Campus, Aurora, Colorado.
Kristopher OpronDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
John R Erb-DownwardDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Lesa A BegleyDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Gen LiDepartment of Biostatistics, School of Public Health.
Igor BarjaktarevicUniversity of California at Los Angeles, Los Angeles, California.
R Graham BarrDepartment of Medicine and.
Alejandro P ComellasUniversity of Iowa, Iowa City, Iowa.ORCID 0000-0003-1521-7520
David J CouperDepartment of Biostatistics.
Christopher B CooperUniversity of California at Los Angeles, Los Angeles, California.
Christine M FreemanDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
MeiLan K HanDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Robert J KanerWeill Cornell Medical College, New York, New York.
Wassim LabakiDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Fernando J MartinezWeill Cornell Medical College, New York, New York.
Victor E OrtegaWake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Stephen P PetersWake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Robert PaineUniversity of Utah, Salt Lake City, Utah.
Prescott WoodruffUniversity of California at San Francisco, San Francisco, California.
Jeffrey L CurtisDivision of Pulmonary and Critical Care Medicine, Department of Medicine.ORCID 0000-0001-5191-4847
Gary B HuffnagleDivision of Pulmonary and Critical Care Medicine, Department of Medicine.
Kathleen A StringerDepartment of Clinical Pharmacy, College of Pharmacy, and.ORCID 0000-0003-0238-7774
Russell P BowlerSchool of Medicine, University of Colorado, Aurora, Colorado; and.
Charles R EstherDivision of Pediatric Pulmonology, and.
Nichole ReisdorphDepartment of Pharmaceutical Sciences, University of Colorado, Anschutz Campus, Aurora, Colorado.
Yvonne J HuangDivision of Pulmonary and Critical Care Medicine, Department of Medicine.ORCID 0000-0002-7497-6597
SPIROMICS Research Group
Pulmonary and Critical Care Associates · USCornell University · USUniversity of California, Los Angeles · USUniversity of Colorado Anschutz Medical Campus · USWake Forest University · USCancer Research And Biostatistics · USColumbia University Irving Medical Center · USInstitut thématique Génétique, génomique et bioinformatique · FRNational Jewish Health · USUniversity of California, San Francisco · USUniversity of Iowa · USUniversity of Michigan · USUniversity of North Carolina at Chapel Hill · USUniversity of Utah · USVA Ann Arbor Healthcare System · US
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MSPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2MSputum Microbial Markers of Type 2-Low AsthmaR01AI129958 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUANG, YVONNE JEAN · 2017 to 2021
$3.6MFunctional Analysis of the Pulmonary Microbiome during COPDR01HL121774 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUFFNAGLE, GARY B · 2017 to 2020
$3.1MNHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS R01 HL121774NHLBI NIH HHS R01HL121774NHLBI NIH HHS R01HL121774-S1NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIAID NIH HHS R01 AI129958NIEHS NIH HHS P30 ES005605
Abstract
PubMed holds no abstract for this paper.
Indexed as
MicrobiotaPulmonary Disease, Chronic ObstructiveAdenosineHumansLungRNA, Ribosomal, 16SAdenosineRNA, Ribosomal, 16Sbronchoscopychronic obstructive pulmonary diseaselung functionmetabolomics
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT01969344ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.