Evidence map›Paper›PMID 35536659›Full record

ArticleJournal of proteome research2022

Ion-Pairing Chromatography and Amine Derivatization Provide Complementary Approaches for the Targeted LC-MS Analysis of the Polar Metabolome.

Virag Sagi-Kiss, Yufeng Li, Matthew R Carey, Sarah J Grover, Karsten Siems, Francesca Cirulli, Alessandra Berry, Chiara Musillo, Ian D Wilson, Elizabeth J Want and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of proteome research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  8. Dyskeratosis Congenita Links Telomere Attrition to 
Age-Related Systemic Energetics.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Virag Sagi-KissDepartment of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London SW7 2AZ, U.K.
Yufeng LiDepartment of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London SW7 2AZ, U.K.
Matthew R CareyDepartment of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London SW7 2AZ, U.K.ORCID 0000-0002-7982-4904
Sarah J GroverDepartment of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London SW7 2AZ, U.K.
Karsten SiemsAnalytiCon Discovery GmbH, Hermannswerder Haus 17, 14473 Potsdam, Germany.
Francesca CirulliCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena, 00161 Rome, Italy.
Alessandra BerryCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena, 00161 Rome, Italy.
Chiara MusilloCenter for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Viale Regina Elena, 00161 Rome, Italy.
Ian D WilsonDepartment of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London SW7 2AZ, U.K.ORCID 0000-0002-8558-7394
Elizabeth J WantDepartment of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London SW7 2AZ, U.K.ORCID 0000-0002-7433-8632
Jacob G BundyDepartment of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington, London SW7 2AZ, U.K.ORCID 0000-0002-1164-8465
Imperial College London · GBIstituto Superiore di Sanità · IT

Funding

Biotechnology and Biological Sciences Research Council
6 · The paper itself

Abstract

Liquid chromatography coupled to mass spectrometry is a key metabolomics/metabonomics technology. Reversed-phase liquid chromatography (RPLC) is very widely used as a separation step, but typically has poor retention of highly polar metabolites. Here, we evaluated the combination of two alternative methods for improving retention of polar metabolites based on 6-aminoquinoloyl-

Indexed as

AminesTandem Mass SpectrometryAnimalsChromatography, LiquidFemaleMaleMetabolomeMetabolomicsMiceAminesampelopsinhealthy agingion-pairingmetabolomicsmetabonomicsNMR spectroscopystatistical heterospectroscopyUPLC-MS

Identifiers

PMID35536659
PMCPMC9171846
OpenAlexW4229441502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.