ArticleeLife2022
Role of anterior insula cortex in context-induced relapse of nicotine-seeking.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.Molecular psychiatry · 2026Article
- Anterior Insula Activity during Alcohol and Social Reward Self-Administration and Choice in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Renewal and reacquisition of substance-associated relapse.Frontiers in psychology · 2026Review
- Dual Role of LH-GABA Neurons in Encoding Alcohol Reward and Aversive Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Regulation of addiction by the insular cortex: The interplay between interoception and cognitive function.iScience · 2025Review
- Article
- Obtaining artifact-corrected signals in fiber photometry via isosbestic signals, robust regression, and dF/F calculations.Neurophotonics · 2025Article
- Remission from addiction: erasing the wrong circuits or making new ones?Nature reviews. Neuroscience · 2025Review
- Punishment-resistant alcohol intake is mediated by the nucleus accumbens shell in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Acute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement.Psychopharmacology · 2024Article
- Insular cortex subregions have distinct roles in cued heroin seeking after extinction learning and prolonged withdrawal in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Adolescent nicotine exposure promotes adulthood opioid consumption that persists despite adverse consequences and increases the density of insular perineuronal nets.Addiction neuroscience · 2024Article
- The anterior insula and its projection to amygdala nuclei modulate the abstinence-exacerbated expression of conditioned place preference.Psychopharmacology · 2024Article
- The therapeutic potential of low-intensity focused ultrasound for treating substance use disorder.Frontiers in psychiatry · 2024Review
- Still a "hidden island"? The rodent insular cortex in drug seeking, reward, and risk.Neuroscience and biobehavioral reviews · 2023Review
- Pathways to the persistence of drug use despite its adverse consequences.Molecular psychiatry · 2023Review
- Role of Piriform Cortex and Its Afferent Projections in Relapse to Fentanyl Seeking after Food Choice-Induced Voluntary Abstinence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- CaMKIIα neurons in the anterior insular cortex regulate attention behavior in mice.Frontiers in neural circuits · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tobacco use is the leading cause of preventable death worldwide, and relapse during abstinence remains the critical barrier to successful treatment of tobacco addiction. During abstinence, environmental contexts associated with nicotine use can induce craving and contribute to relapse. The insular cortex (IC) is thought to be a critical substrate of nicotine addiction and relapse. However, its specific role in context-induced relapse of nicotine-seeking is not fully known. In this study, we report a novel rodent model of context-induced relapse to nicotine-seeking after punishment-imposed abstinence, which models self-imposed abstinence through increasing negative consequences of excessive drug use. Using the neuronal activity marker Fos we find that the anterior (aIC), but not the middle or posterior IC, shows increased activity during context-induced relapse. Combining Fos with retrograde labeling of aIC inputs, we show projections to aIC from contralateral aIC and basolateral amygdala exhibit increased activity during context-induced relapse. Next, we used fiber photometry in aIC and observed phasic increases in aIC activity around nicotine-seeking responses during self-administration, punishment, and the context-induced relapse tests. Next, we used chemogenetic inhibition in both male and female rats to determine whether activity in aIC is necessary for context-induced relapse. We found that chemogenetic inhibition of aIC decreased context-induced nicotine-seeking after either punishment- or extinction-imposed abstinence. These findings highlight the critical role nicotine-associated contexts play in promoting relapse, and they show that aIC activity is critical for this context-induced relapse following both punishment and extinction-imposed abstinence.
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