Evidence map›Paper›PMID 35536587›Full record

ArticleJournal of extracellular vesicles2022

Extracellular vesicles enclosed-miR-421 suppresses air pollution (PM

Hongyun Wang, Tianhui Wang, Wei Rui, Jinxin Xie, Yuling Xie, Xiao Zhang, Longfei Guan, Guoping Li, Zhiyong Lei, Raymond M Schiffelers and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of extracellular vesicles, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

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  6. GEVResearch (Washington, D.C.) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Hongyun WangInstitute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.ORCID 0000-0003-2417-5924
Tianhui WangInstitute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.
Wei RuiInstitute for Immunology, Tsinghua University, Beijing, China.
Jinxin XieInstitute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.
Yuling XieInstitute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.
Xiao ZhangInstitute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.
Longfei GuanChina-America Institute Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Guoping LiCardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Zhiyong LeiCDL Research, University Medical Center Utrecht, Utrecht, The Netherlands.
Raymond M SchiffelersCDL Research, University Medical Center Utrecht, Utrecht, The Netherlands.
Joost P G SluijterDepartment of Cardiology, Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Junjie XiaoInstitute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong, China.ORCID 0000-0002-9202-0003
Shanghai University · CNUtrecht University · NLBeijing Luhe Hospital Affiliated to Capital Medical University · CNHarvard University · USTsinghua University · CN

Funding

"Chenguang Program" of Shanghai Education Development Foundation and Shanghai Municipal Education Commission 20CG46Horizon2020 ERC-2016-COG EVICARE 725229National Key Research and Development Project 2018YFE0113500National Natural Science Foundation of China 81600008National Natural Science Foundation of China 81911540486National Natural Science Foundation of China 82000253National Natural Science Foundation of China 82020108002Science and Technology Commission of Shanghai Municipality 20DZ2255400Science and Technology Commission of Shanghai Municipality 21XD1421300the "Dawn" Program of Shanghai Education Commission 19SG34the Sailing Program from Science and Technology Commission of Shanghai 20YF1414000
6 · The paper itself

Abstract

Air pollution, via ambient PM

Indexed as

Air PollutionExtracellular VesiclesHeart DiseasesLung InjuryMicroRNAsAngiotensin-Converting Enzyme 2AnimalsMiceMyocytes, CardiacParticulate MatterRatsAngiotensin-Converting Enzyme 2MicroRNAsParticulate MatterACE2cardiac dysfunctionextracellular vesiclesmiR-421PM2.5

Identifiers

PMID35536587
PMCPMC9089227
OpenAlexW4280626186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.