ArticleMolecular biology reports2022
Investigation of HER-3 gene expression under the influence of carbohydrate biopolymers extract of shiitake and reishi in MCF-7 cell line.
Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 12 citations in OpenAlex.
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- From Phytochemical Characterization to Energy Metabolism-Driven Molecular Responses: The Anticancer Potential ofNutrients · 2026Article
- Fungi as a source of anticancer agents: metabolic products and their functional implications.Archives of microbiology · 2026Review
- Unveiling Transcriptional Dynamics Across Five Developmental Stages of the Edible MushroomJournal of fungi (Basel, Switzerland) · 2026Article
- Critical Review on the Anti-Tumor Activity of Bioactive Compounds from Edible and Medicinal Mushrooms over the Last Five Years.Nutrients · 2025Review
- Synergistic Photothermal Therapy and Chemotherapy Enabled by Tumor Microenvironment-Responsive Targeted SWCNT Delivery.International journal of molecular sciences · 2024Article
- Effects of Cold Plasma Pretreatment on the Synthesis of Polysaccharide from Pleurotus ostreatus.Applied biochemistry and biotechnology · 2024Article
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Authors and funding
1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionEdible-medicinal fungi are mainly used in Asian countries to prevent various diseases. These mushrooms are also used to treat lung diseases and cancer. Ganoderma lucidum and Lentinula edodes are the most important edible-medicinal fungi. The polysaccharides of these fungi are one of the bioactive compounds with anti-cancer properties.
objectiveEvaluation of anti-cancer effects of Shiitake and Reishi polysaccharides.
methodsIn this study, fungal polysaccharides were extracted using the hot water method and were purified by Diethylaminoethyl Sephadex A-25 (DEAE-Sephadex A-25) chromatography column and their concentration was measured by phenolic sulfuric acid method. The biological effects of the extracted polysaccharides from Ganoderma lucidum and Lentinula edodes on the MCF-7 cell line were investigated using an MTT assay and then its effects on the expression of the P53 cancer regulatory gene and HER-3 gene were investigated.
resultsBased on the results, the concentration of Ganoderma lucidum and Lentinula edodes extracted polysaccharides were 0.024 and 0.103 mg/ml, respectively. Polysaccharides of these two fungi increased the expression of the P53 gene and decreased the expression of the HER-3 gene in a dose and time-dependent manner. DISCUSSION: Natural biocompatible polysaccharides with anti-cancer properties that are native, are available, and inexpensive, so they can be used as dietary supplements to prevent and help treat cancer.
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