Evidence map›Paper›PMID 35536444›Full record

ArticleCell and tissue research2022

Mesenchymal stem cell treatment for enteric neuropathy in the Winnie mouse model of spontaneous chronic colitis.

Ainsley M Robinson, Rhian Stavely, Sarah Miller, Rajaraman Eri, Kulmira Nurgali

Abstract read
PubMed Publisher
In one paragraph

Article in Cell and tissue research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Ainsley M RobinsonInstitute for Health and Sport, Victoria University; Western Centre for Health, Research and Education, Sunshine Hospital, Melbourne, VIC, Australia.
Rhian StavelyInstitute for Health and Sport, Victoria University; Western Centre for Health, Research and Education, Sunshine Hospital, Melbourne, VIC, Australia.
Sarah MillerInstitute for Health and Sport, Victoria University; Western Centre for Health, Research and Education, Sunshine Hospital, Melbourne, VIC, Australia.
Rajaraman EriUniversity of Tasmania, School of Health Sciences, Launceston, TAS, Australia.
Kulmira NurgaliInstitute for Health and Sport, Victoria University; Western Centre for Health, Research and Education, Sunshine Hospital, Melbourne, VIC, Australia. kulmira.nurgali@vu.edu.au.ORCID http://orcid.org/0000-0002-2597-6929
Sunshine Hospital · AUMassachusetts General Hospital · USThe University of Melbourne · AUUniversity of Tasmania · AU

Funding

Victoria University Development GrantVictoria University Research
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is a chronic gut inflammation with periods of acute flares and remission. Beneficial effects of a single dose of mesenchymal stem cell (MSC)-based treatment have been demonstrated in acute models of colitis. No studies investigated therapeutic effects of MSCs for the attenuation of enteric neuropathy in a chronic model of colitis. The short and long-term effects of MSC treatment in modulating inflammation and damage to the enteric nervous system (ENS) were studied in the Winnie mouse model of spontaneous chronic colitis highly representative of human IBD. Winnie mice received a single dose of either 1 × 10

Indexed as

ColitisInflammatory Bowel DiseasesIntestinal Pseudo-ObstructionMesenchymal Stem CellsMesenchymal Stem Cell TransplantationAnimalsDisease Models, AnimalInflammationMiceMice, Inbred C57BLEnteric nervous systemEnteric neuropathyInflammatory bowel diseaseIntestinal inflammationMesenchymal stem cellsSpontaneous chronic colitis

Identifiers

PMID35536444
OpenAlexW4229450662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.