Evidence map›Paper›PMID 35536239›Full record

ArticleCirculation. Genomic and precision medicine2022

Population Prevalence of Premature Truncating Variants in Plakophilin-2 and Association With Arrhythmogenic Right Ventricular Cardiomyopathy: A UK Biobank Analysis.

Robyn J Hylind, Alexandre C Pereira, Daniel Quiat, Stephanie F Chandler, Thomas M Roston, William T Pu, Vassilios J Bezzerides, Jonathan G Seidman, Christine E Seidman, Dominic J Abrams

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Genomic and precision medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Robyn J HylindInherited Cardiac Arrhythmia Program, Department of Cardiology, Boston Children's Hospital (R.J.H., D.Q., S.F.C., T.M.R., W.T.P., V.J.B., D.J.A.), Harvard Medical School, Boston MA.ORCID 0000-0002-8280-4541
Alexandre C PereiraDepartment of Genetics (A.C.P., D.Q., J.G.S., C.E.S.), Harvard Medical School, Boston MA.ORCID 0000-0002-7782-5540
Daniel QuiatInherited Cardiac Arrhythmia Program, Department of Cardiology, Boston Children's Hospital (R.J.H., D.Q., S.F.C., T.M.R., W.T.P., V.J.B., D.J.A.), Harvard Medical School, Boston MA.ORCID 0000-0002-4224-7277
Stephanie F ChandlerInherited Cardiac Arrhythmia Program, Department of Cardiology, Boston Children's Hospital (R.J.H., D.Q., S.F.C., T.M.R., W.T.P., V.J.B., D.J.A.), Harvard Medical School, Boston MA.
Thomas M RostonInherited Cardiac Arrhythmia Program, Department of Cardiology, Boston Children's Hospital (R.J.H., D.Q., S.F.C., T.M.R., W.T.P., V.J.B., D.J.A.), Harvard Medical School, Boston MA.ORCID 0000-0001-5663-4377
William T PuInherited Cardiac Arrhythmia Program, Department of Cardiology, Boston Children's Hospital (R.J.H., D.Q., S.F.C., T.M.R., W.T.P., V.J.B., D.J.A.), Harvard Medical School, Boston MA.ORCID 0000-0002-4551-8079
Vassilios J BezzeridesInherited Cardiac Arrhythmia Program, Department of Cardiology, Boston Children's Hospital (R.J.H., D.Q., S.F.C., T.M.R., W.T.P., V.J.B., D.J.A.), Harvard Medical School, Boston MA.
Jonathan G SeidmanDepartment of Genetics (A.C.P., D.Q., J.G.S., C.E.S.), Harvard Medical School, Boston MA.ORCID 0000-0002-9082-3566
Christine E SeidmanDepartment of Genetics (A.C.P., D.Q., J.G.S., C.E.S.), Harvard Medical School, Boston MA.ORCID 0000-0001-6380-1209
Dominic J AbramsInherited Cardiac Arrhythmia Program, Department of Cardiology, Boston Children's Hospital (R.J.H., D.Q., S.F.C., T.M.R., W.T.P., V.J.B., D.J.A.), Harvard Medical School, Boston MA.ORCID 0000-0001-5266-2805
Boston Children's Hospital · USHarvard University · USBrigham and Women's Hospital · US

Funding

RESEARCH METHODS IN PEDIATRICS HEART DISEASET32HL007572 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI Sarah D DE FERRANTI, Jane W. Newburger · 1985 to 2026
$13.0M
Defining Pathways from Gene Mutation to Heart FailureR01HL080494 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CHEN, CHRISTOPHER S, SEIDMAN, CHRISTINE E · 2005 to 2024
$9.4M
Molecular Signaling in Hypertrophic CardiomyopathyR01HL084553 · NHLBI · HARVARD MEDICAL SCHOOL · PI SEIDMAN, JONATHAN G · 2007 to 2022
$5.9M
Novel molecular therapies for CPVTK08HL140197 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI BEZZERIDES, VASSILIOS JAMES · 2018 to 2022
$851k
Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NHLBI NIH HHS K08 HL140197NHLBI NIH HHS R01 HL080494NHLBI NIH HHS R01 HL084553NHLBI NIH HHS T32 HL007572
6 · The paper itself

Abstract

backgroundTruncating variants in the desmosomal gene

methodsWe identified individuals with

results

conclusions

Indexed as

Arrhythmogenic Right Ventricular DysplasiaPlakophilinsGenetics, PopulationHumansPrevalenceUnited KingdomPKP2 protein, humanPlakophilinsatrial fibrillationcardiomyopathiesplakophilinspopulationrisk factors

Identifiers

PMID35536239
PMCPMC9400410
OpenAlexW4280506613

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.