Evidence map›Paper›PMID 35536178›Full record

Observational studyRheumatology (Oxford, England)2022

Worse outcomes linked to ethnicity for early inflammatory arthritis in England and Wales: a national cohort study.

Maryam A Adas, Sam Norton, Sathiyaa Balachandran, Edward Alveyn, Mark D Russell, Thomas Esterine, Paul Amlani-Hatcher, Sarah Oyebanjo, Heidi Lempp, Joanna Ledingham and 3 more

Open access · bronzeAbstract readObservational Study
In one paragraph

Observational study in Rheumatology (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Maryam A AdasCentre for Rheumatic Disease, Department of Inflammatory Biology.ORCID 0000-0002-5560-6603
Sam NortonCentre for Rheumatic Disease, Department of Inflammatory Biology.ORCID 0000-0003-1714-9963
Sathiyaa BalachandranCentre for Rheumatic Disease, Department of Inflammatory Biology.
Edward AlveynCentre for Rheumatic Disease, Department of Inflammatory Biology.
Mark D RussellCentre for Rheumatic Disease, Department of Inflammatory Biology.ORCID 0000-0001-8171-7772
Thomas EsterineBritish Society for Rheumatology, NEIAA Patient Panel.
Paul Amlani-HatcherBritish Society for Rheumatology, NEIAA Patient Panel.
Sarah OyebanjoBritish Society of Rheumatology, NEIAA, London.
Heidi LemppCentre for Rheumatic Disease, Department of Inflammatory Biology.
Joanna LedinghamRheumatology Department, Portsmouth Hospitals University NHS Trust, Portsmouth.
Kanta KumarInstitute of Clinical Sciences, University of Birmingham, Birmingham.
James B GallowayCentre for Rheumatic Disease, Department of Inflammatory Biology.
Shirish DubeyOxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID 0000-0002-9979-6066
British Society for Rheumatology · GBKing's College London · GBOxford University Hospitals NHS Trust · GBPortsmouth Hospitals NHS Trust · GBUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess variability in care quality and treatment outcomes across ethnicities in early inflammatory arthritis (EIA).

methodsWe conducted an observational cohort study in England and Wales from May 2018 to March 2020, including patients with a suspected/confirmed EIA diagnosis. Care quality was assessed against six metrics defined by national guidelines. Clinical outcomes were measured using DAS28. Outcomes between ethnic groups ('White', 'Black', 'Asian', 'Mixed', 'Other') were compared, and adjusted for confounders.

resultsA total of 35 807 eligible patients were analysed. Of those, 30 643 (85.6%) were White and 5164 (14.6%) were from ethnic minorities: 1035 (2.8%) Black; 2617 (7.3%) Asian; 238 (0.6%) Mixed; 1274 (3.5%) Other. In total, 12 955 patients had confirmed EIA, of whom 11 315 were White and 1640 were from ethnic minorities: 314 (2.4%) Black; 927 (7.1%) Asian; 70 (0.5%) Mixed; 329 (2.5%) Other. A total of 14 803 patients were assessed by rheumatology within three weeks, and 5642 started treatment within six weeks of referral. There were no significant differences by ethnicity. Ethnic minority patients had lower odds of disease remission at three months [adjusted odds ratio 0.79 (95% CI: 0.65, 0.96)] relative to White patients. Ethnic minorities were significantly less likely to receive initial treatment withMTX[0.68 (0.52, 0.90)] or with glucocorticoids [0.63 (0.49, 0.80)].

conclusionWe demonstrate that some ethnic minorities are less likely to achieve disease remission in three months following EIA diagnosis. This is not explained by delays in referral or time to treatment. Our data highlight the need for investigation into the possible drivers of these inequitable outcomes and reappraisal of EIA management pathways.

Indexed as

ArthritisEthnicityCohort StudiesEnglandHumansMinority GroupsWalesAsianBlackcare qualityDAS28disease outcomeDMARDearly inflammatory arthritisethnic minoritiesMixedOther

Identifiers

PMID35536178
PMCPMC9788810
OpenAlexW4280596070

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.