ArticleMicrobiology spectrum2022
Metabolic Synergy between Human Symbionts
Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 34 citations in OpenAlex.
- Long-term health outcomes in adolescents with obesity treated with faecal microbiota transplantation: 4-year follow-up.Nature communications · 2025Trial
- Methanogenesis associated with altered microbial production of short-chain fatty acids and human-host metabolizable energy.The ISME journal · 2025Trial
- Methanogens: vital but threatened members of the human microbiome?Trends in microbiology · 2026Review
- Multi-omics revealed the effects of rumen to blood path on early lactation performance in transition dairy cows.Microbiome · 2026Article
- Niche specialization and cross-feeding interactions shaping gut microbial fiber degradation in a model omnivore.bioRxiv : the preprint server for biology · 2026Article
- Improving DirectLiNGAM for high-dimensional microbiome data: roots screening and eBIC based model selection.Frontiers in systems biology · 2026Article
- Caenorhabditis elegans microbiome members have combinatorial effects on host survival and fitness.Scientific reports · 2025Article
- Comparing alignment and de-novo approaches for gut microbiota metagenomic data analysis reveals differences in taxonomic resolution and novel functional insights.Scientific reports · 2025Article
- Archaeal diversity in the microbiomes of four wild bird species.Microbiology spectrum · 2025Article
- Perioperative Multi-Kingdom Gut Microbiota Alters in Coronary Artery Bypass Grafting.Biomedicines · 2025Article
- Mechanisms underlying alterations of the gut microbiota by exercise and their role in shaping ecological resilience.FEMS microbiology reviews · 2025Review
- Core cooperative metabolism in low-complexity CO2-fixing anaerobic microbiota.The ISME journal · 2025Article
- Superior ability of dietary fiber utilization in obese breed pigs linked to gut microbial hydrogenotrophy.ISME communications · 2025Article
- Microbial transcriptional responses to host diet maintain gut microbiome homeostasis in the American cockroach.bioRxiv : the preprint server for biology · 2024Article
- Microbes as medicine.Annals of the New York Academy of Sciences · 2024Review
- Review
- Bacterial interactions on nutrient-rich surfaces in the gut lumen.Infection and immunity · 2024Review
- Targeted isolation of Methanobrevibacter strains from fecal samples expands the cultivated human archaeome.Nature communications · 2024Article
- Analysis of Human Milk Microbiota in Northern Greece by Comparative 16S rRNA Sequencing vs. Local Dairy Animals.Nutrients · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Trophic interactions between microbes are postulated to determine whether a host microbiome is healthy or causes predisposition to disease. Two abundant taxa, the Gram-negative heterotrophic bacterium Bacteroides thetaiotaomicron and the methanogenic archaeon Methanobrevibacter smithii, are proposed to have a synergistic metabolic relationship. Both organisms play vital roles in human gut health; B. thetaiotaomicron assists the host by fermenting dietary polysaccharides, whereas M. smithii consumes end-stage fermentation products and is hypothesized to relieve feedback inhibition of upstream microbes such as B. thetaiotaomicron. To study their metabolic interactions, we defined and optimized a coculture system and used software testing techniques to analyze growth under a range of conditions representing the nutrient environment of the host. We verify that B. thetaiotaomicron fermentation products are sufficient for M. smithii growth and that accumulation of fermentation products alters secretion of metabolites by B. thetaiotaomicron to benefit M. smithii. Studies suggest that B. thetaiotaomicron metabolic efficiency is greater in the absence of fermentation products or in the presence of M. smithii. Under certain conditions, B. thetaiotaomicron and M. smithii form interspecies granules consistent with behavior observed for syntrophic partnerships between microbes in soil or sediment enrichments and anaerobic digesters. Furthermore, when vitamin B
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.