Evidence map›Paper›PMID 35536001›Full record

ArticlemBio2022

Microbiome Profiling of Enterotoxigenic Escherichia coli (ETEC) Carriers Highlights Signature Differences between Symptomatic and Asymptomatic Individuals.

Ellen E Higginson, M Abu Sayeed, Joana Pereira Dias, Vignesh Shetty, Mamatha Ballal, Sunil Kumar Srivastava, Ian Willis, Firdausi Qadri, Gordon Dougan, Ankur Mutreja

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. The potential of yeast culture for alleviating enterotoxigenicAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Fecal microbiome profiling of children withMicrobiology spectrum · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Colonizing and Virulence Factors in Enterotoxigenic Escherichia coli from Peru.The American journal of tropical medicine and hygiene · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Ellen E HigginsonCambridge Institute for Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-9218-1627
M Abu SayeedInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
Joana Pereira DiasCambridge Institute for Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Vignesh ShettyCambridge Institute for Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Mamatha BallalEnteric Diseases Division, Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Sunil Kumar SrivastavaUniversity of Delhi, Delhi, India.
Ian WillisEMBL-EBI, Hinxton, United Kingdom.
Firdausi QadriInternational Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Bangladesh.
Gordon DouganCambridge Institute for Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Ankur MutrejaCambridge Institute for Therapeutic Immunology and Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-1118-8075
University of Cambridge · GBInternational Centre for Diarrhoeal Disease Research · BDManipal Academy of Higher Education · INEuropean Bioinformatics Institute · GBUniversity of Delhi · IN

Funding

Wellcome TrustWellcome Trust (WT) 106158/Z/14/Z
6 · The paper itself

Abstract

Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea in children in low- and middle-income countries (LMICs). However, large-scale pathogen burden studies in children have identified ETEC in the guts of both symptomatic patients and controls. The factors that influence this balance are poorly understood, but it is postulated that the gut microbiome may play a role in either resistance or progression to disease. In this study, we profiled the microbiomes of children and adults from Bangladesh who were asymptomatically or symptomatically infected with ETEC. Symptomatic patients had significantly higher numbers of sequenced reads mapping to both E. coli and two ETEC toxins, suggesting higher bacterial burden. They were also significantly more likely to be coinfected with enteroaggregative E. coli (EAEC) and had higher proportions of other

Indexed as

Enterotoxigenic Escherichia coliEscherichia coli InfectionsGastrointestinal MicrobiomeMicrobiotaAdultBacteriaChildDiarrheaHumansETECmetagenomicsmicrobiome

Identifiers

PMID35536001
PMCPMC9239084
OpenAlexW4280498472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.