Evidence map›Paper›PMID 35535729›Full record

ArticleMycoses2022

Disinfection trials with terbinafine-susceptible and terbinafine-resistant dermatophytes.

Kristoffer Nagy Skaastrup, Karen Marie Thyssen Astvad, Maiken Cavling Arendrup, Gregor Borut Ernst Jemec, Ditte Marie Lindhardt Saunte

Open access · hybridAbstract read
In one paragraph

Article in Mycoses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pediatric dermatophyte onychomycosis: a review.International journal of dermatology · 2025
    Pooled it
  2. Trichophyton indotineae: Epidemiology, antifungal resistance and antifungal stewardship strategies.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Terbinafine Resistance inAntibiotics (Basel, Switzerland) · 2025
    Review
  7. Tinea pedis: an updated review.Drugs in context · 2023
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kristoffer Nagy SkaastrupDepartment of Dermatology, Zealand University Hospital, Roskilde, Denmark.ORCID https://orcid.org/0000-0003-1550-0537
Karen Marie Thyssen AstvadMycology Unit, Department for Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-4651-2904
Maiken Cavling ArendrupMycology Unit, Department for Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-4747-0144
Gregor Borut Ernst JemecDepartment of Dermatology, Zealand University Hospital, Roskilde, Denmark.ORCID https://orcid.org/0000-0002-0712-2540
Ditte Marie Lindhardt SaunteDepartment of Dermatology, Zealand University Hospital, Roskilde, Denmark.ORCID https://orcid.org/0000-0001-7953-1047
Statens Serum Institut · DKUniversity of Copenhagen · DK

Funding

ElectroluxGRUNDIG NORDIC
6 · The paper itself

Abstract

backgroundTreatment of tinea pedis and onychomycosis is complicated by high rates of reinfection and the emergence of terbinafine-resistant strains of Trichophyton spp. Effective disinfection of contaminated socks is an important measure. Appropriate washing reduces the risk of reinfection and is paramount in treating tinea pedis and onychomycosis.

objectivesThe aim of this study was to describe the effect of commonplace disinfection methods using socks pieces inoculated with terbinafine-resistant or terbinafine-susceptible isolates of Trichophyton spp.

methodsSock pieces were inoculated with seven terbinafine-resistant isolates of Trichophyton spp. with known mutations in the SQLE-gene (T. rubrum (n = 3), T. interdigitale (n = 1) and T. indotineae (n = 3)) and six terbinafine-susceptible isolates of Trichophyton spp. (T. rubrum (n = 3) and T. interdigitale (n = 3)). Methods of disinfection included soaking in a quaternary ammonium (QAC) detergent (0.5, 2 and 24 h), freezing at -20°C (0.5, 12 and 24 h), domestic and steam washing (both at 40°C with detergent). Sock pieces were cultured for 4 weeks following disinfection. The primary end point was no growth at the end of week 4.

resultsSoaking in a QAC-detergent for 24 h procured at disinfectant rate of 100% (13/13), whilst soaking in 0.5 and 2 h had a disinfectant rate of 46.2% (6/13) and 84.6% (11/13), respectively. Domestic washing (40°C with detergent) produced a disinfectant rate of 7.7% (1/13). Freezing at -20°C (0.5, 12 and 24 h) and steam washing (40°C with detergent) had no disinfectant properties.

conclusionsSoaking in a QAC-detergent for 24 h effectively disinfected sock pieces contaminated with dermatophytes.

Indexed as

ArthrodermataceaeDisinfectantsOnychomycosisAntifungal AgentsDetergentsDisinfectionDrug Resistance, FungalHumansMicrobial Sensitivity TestsReinfectionSteamTerbinafineTinea PedisTrichophytonAntifungal AgentsDetergentsDisinfectantsSteamTerbinafinedermatophytosisonychomycosisterbinafine resistancetineaTrichophyton

Identifiers

PMID35535729
PMCPMC10138727
OpenAlexW4229453622

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.