ArticleJournal of the American Geriatrics Society2022
Increased multimorbidity is associated with impaired cerebral and peripheral hemodynamic stabilization during active standing.
Article in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Cerebral oxygenation response to postural change using continuous near-infrared spectroscopy (NIRS) and its association with falls in older adults.European geriatric medicine · 2026Article
- Linking Neurocardiovascular Responses in the Active Stand Test to Adverse Outcomes: Insights from the Irish Longitudinal Study on Ageing (TILDA).Sensors (Basel, Switzerland) · 2025Article
- Preoperative physical resilience indicators and their associations with postoperative outcomes.GeroScience · 2025Article
- Review of Blood Pressure Control in Vulnerable Older Adults: The Role of Frailty and Sarcopenia.Journal of vascular diseases · 2025Article
- The Impact of Type 2 Diabetes on Peripheral and Cerebral Hemodynamic Responses to Active Stand.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Associations of Orthostatic Hypotension and Frailty With Dementia and Mortality in Older Adults: A Population-Based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Were Frailty Identification Criteria Created Equal? A Comparative Case Study on Continuous Non-Invasively Collected Neurocardiovascular Signals during an Active Standing Test in the Irish Longitudinal Study on Ageing (TILDA).Sensors (Basel, Switzerland) · 2024Observational
- Slower speed of blood pressure recovery after standing is associated with accelerated brain aging: Evidence from The Irish Longitudinal Study on Ageing (TILDA).Cerebral circulation - cognition and behavior · 2024Article
- Haemodynamic Parameters Underlying the Relationship between Sarcopenia and Blood Pressure Recovery on Standing.Journal of clinical medicine · 2023Article
- Prospective association of occupational and leisure-time physical activity with orthostatic blood pressure changes in older adults.Scientific reports · 2023Article
- Safety and feasibility of transcutaneous vagus nerve stimulation in mild cognitive impairment: VINCI-AD study protocol.BMC neurology · 2023Article
- Cerebral Oxygenation Responses to Standing in Young Patients with Vasovagal Syncope.Journal of clinical medicine · 2023Article
- Increased multimorbidity is associated with impaired cerebral and peripheral hemodynamic stabilization during active standing.Journal of the American Geriatrics Society · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundAge-related morbidities and frailty are associated with impaired blood pressure (BP) and heart rate (HR) recovery after standing. Here we investigate how multimorbidity affects cerebral and peripheral hemodynamics during standing in a large sample of older patients.
methodsPatients were recruited from a national Falls and Syncope Unit. They underwent an active stand test (5-10 min lying +3 min standing) with monitoring of continuous BP, HR, total peripheral resistance (TPR), stroke volume (SV), and a near-infrared spectroscopy (NIRS) derived cerebral tissue saturation index (TSI). A multimorbidity count was derived from a 26-item list of conditions. Features derived from the signals included: nadir, overshoot, value at 30 s, steady-state and recovery rate. Robust linear regression was used to assess the association between multimorbidity, TSI and peripheral hemodynamics while correcting for covariates. A p-value <0.05 was considered statistically significant.
resultsMultimorbidity was associated with poorer recovery of TSI at 30 s after standing (β: -0.15, CI:[-0.25-0.06], p = 0.009) independent of all peripheral hemodynamics. Impaired diastolic BP (DBP) recovery at 30s (β:-1.34, CI:[-2.29-0.40], p = 0.032), DBP steady-state (β:-1.18, CI:[-2.04-0.32], p = 0.032), TPR overshoot-to-nadir difference (β:-0.041, CI:[-0.070-0.013], p = 0.045), and SV at 30s (β:1.30, CI:[0.45 2.15], p = 0.027) were also associated with increasing multimorbidity. After sex stratification, only females demonstrated impaired TSI with multimorbidity at overshoot (β: -0.19, CI: [-0.32 -0.07], p = 0.009), 30 s (β: -0.22 [-0.35-0.10], p = 0.005) and steady-state (β: -0.20, CI:[-0.35-0.04], p = 0.023), independent of peripheral hemodynamics.
conclusionsTransient cerebral oxygenation and peripheral hemodynamic responses are impaired with multimorbidity (frailty) in older patients, particularly in females. This study demonstrates the feasibility of using NIRS in this clinical context and may inform the development of clinical management strategies targeting both cerebral oxygenation and blood pressure impairments in patients with faints and falls.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.