Evidence map›Paper›PMID 35535614›Full record

ArticleJournal of the American Heart Association2022

Myeloid Poldip2 Contributes to the Development of Pulmonary Inflammation by Regulating Neutrophil Adhesion in a Murine Model of Acute Respiratory Distress Syndrome.

Ziwei Ou, Elena Dolmatova, Rohan Mandavilli, Hongyan Qu, Georgette Gafford, Taylor White, Alejandra Valdivia, Bernard Lassègue, Marina S Hernandes, Kathy K Griendling

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Ziwei OuDivision of Cardiology Department of Medicine Emory University Atlanta GA.
Elena DolmatovaDivision of Cardiology Department of Medicine Emory University Atlanta GA.
Rohan MandavilliDivision of Cardiology Department of Medicine Emory University Atlanta GA.ORCID 0000-0002-9240-5368
Hongyan QuDivision of Cardiology Department of Medicine Emory University Atlanta GA.
Georgette GaffordDivision of Cardiology Department of Medicine Emory University Atlanta GA.
Taylor WhiteDivision of Cardiology Department of Medicine Emory University Atlanta GA.
Alejandra ValdiviaDivision of Cardiology Department of Medicine Emory University Atlanta GA.
Bernard LassègueDivision of Cardiology Department of Medicine Emory University Atlanta GA.
Marina S HernandesDivision of Cardiology Department of Medicine Emory University Atlanta GA.ORCID 0000-0001-6238-1441
Kathy K GriendlingDivision of Cardiology Department of Medicine Emory University Atlanta GA.ORCID 0000-0002-9456-8582
Emory University · USCentral South University · CN

Funding

T cell triggering events and hypertensionP01HL095070 · NHLBI · EMORY UNIVERSITY · PI LASSEGUE, BERNARD · 2009 to 2019
$20.5M
Role of Poldip2 in endothelial barrier function and inflammation in the lungR56HL152167 · NHLBI · EMORY UNIVERSITY · PI GRIENDLING, KATHY K · 2020 to 2020
$675k
The role of Poldip2 in macrophages during sepsis-induced lung injuryF32HL151133 · NHLBI · EMORY UNIVERSITY · PI DOLMATOVA, ELENA · 2020 to 2020
$76k
NHLBI NIH HHS F32 HL151133NHLBI NIH HHS P01 HL095070NHLBI NIH HHS R56 HL152167
6 · The paper itself

Abstract

Background Lung injury, a severe adverse outcome of lipopolysaccharide-induced acute respiratory distress syndrome, is attributed to excessive neutrophil recruitment and effector response. Poldip2 (polymerase δ-interacting protein 2) plays a critical role in regulating endothelial permeability and leukocyte recruitment in acute inflammation. Thus, we hypothesized that

Indexed as

Mitochondrial ProteinsNeutrophilsNuclear ProteinsPneumoniaRespiratory Distress SyndromeAnimalsCell AdhesionDisease Models, AnimalFocal Adhesion Kinase 2IntegrinsLipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutFocal Adhesion Kinase 2IntegrinsLipopolysaccharidesMitochondrial Proteinsmitogenin 1 protein, mouseNuclear ProteinsadhesionARDSintegrinneutrophilPoldip2

Identifiers

PMID35535614
PMCPMC9238549
OpenAlexW4280560512

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.