Evidence map›Paper›PMID 35535373›Full record

ReviewJournal of Korean medical science2022

A Review of Sarcopenia Pathophysiology, Diagnosis, Treatment and Future Direction.

Myung-Rae Cho, Sungho Lee, Suk-Kyoon Song

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Korean medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 247 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
247citing papers in PubMed, 11 pooled it
38.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06756399 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Relationship Between Sarcopenia and Peripheral and Respiratory Muscle Strength in Geriatric Individuals

TypeobservationalSponsorBiruni UniversityRan2025 to 2025Enrolled100ConditionsThe Association Between Sarcopenia and the Strength of Peripheral and Respiratory Muscles in Elderly Individuals, Cardiovascular Diseases, Diabetes Mellitus, HypertensionArmsQuestionnare, hand grip and respiratory muscle strength
NCT07356440 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Consumption of Vegetable Protein-enriched Biscuits and Vitamin D Supplementation on the Progression of Sarcopenia in Elderly Subjects

TypeinterventionalSponsorUniversity of UdineRan2025 to 2026Enrolled74ConditionsSarcopenia in Elderly, Sarcopenia, Nutritional Intervention, Microbiome AnalysisArmsVitamin D3 supplement, Protein-enriched biscuits, Control biscuit, Placebo oil
3 · Its place in the literature

Who cites it

247 citing papers in PubMed, 11 syntheses or guidelines pooled it, 348 citations in OpenAlex.

  1. Pooled it
  2. How Pragmatic Are Sarcopenia Intervention Studies? A Systematic Review.Journal of cachexia, sarcopenia and muscle · 2026
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Trial
  13. Effect of Baduanjin Exercise and Resistance Band Training on Sarcopenia in the Elderly: A Randomized Controlled Trial.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Trial
  14. Trial
  15. Trial
  16. [Effect of the Otago Exercise Program on Activities of Daily Living in Older Adults With Sarcopenia].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Trial
  17. Trial
  18. Trial
  19. Trial
  20. Review

187 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Myung-Rae ChoDepartment of Orthopaedic Surgery, Daegu Catholic University Medical Center, Daegu, Korea.ORCID https://orcid.org/0000-0003-2901-9787
Sungho LeeDepartment of Orthopaedic Surgery, Daegu Catholic University Medical Center, Daegu, Korea.ORCID https://orcid.org/0000-0001-8527-4745
Suk-Kyoon SongDepartment of Orthopaedic Surgery, Daegu Catholic University Medical Center, Daegu, Korea. ryansong10@naver.com.ORCID https://orcid.org/0000-0002-3241-5820
Daegu Catholic University Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcopenia is a progressive and generalized loss of skeletal muscle mass and function. The prevalence of sarcopenia was reported to be up to 29% in older persons in the community healthcare setting. Sarcopenia diagnosis is confirmed by the presence of low muscle mass plus low muscle strength or low physical performance. Sarcopenia management options include non-pharmacological and pharmacological approaches. Non-pharmacological approaches include resistance exercise and adequate nutrition. Of the two, resistance exercise is the standard non-pharmacological treatment approach for sarcopenia with significant positive evidence. Some dietary approaches such as adequate intake of protein, vitamin D, antioxidant nutrients, and long-chain polyunsaturated fatty acid have been shown to have positive effects against sarcopenia. Currently, no specific drugs have been approved by the Food and Drug Administration for the treatment of sarcopenia. However, several agents, including growth hormone, anabolic or androgenic steroids, selective androgenic receptor modulators, protein anabolic agents, appetite stimulants, myostatin inhibitors, activating II receptor drugs, β-receptor blockers, angiotensin-converting enzyme inhibitors, and troponin activators, are recommended and have been shown to have variable efficacy. Future research should focus on sarcopenia biological pathway and improved diagnostic approaches such as biomarkers for early detection, development of consistently pre-eminent treatment methods for severe sarcopenia patients, and establishing sensitive measures for predicting sarcopenia treatment response.

Indexed as

SarcopeniaAdrenergic beta-AntagonistsAgedAged, 80 and overExerciseHumansMuscle, SkeletalMuscle StrengthVitaminsAdrenergic beta-AntagonistsVitaminsDiagnosisFutureSarcopeniaTreatment

Identifiers

PMID35535373
PMCPMC9091430
OpenAlexW4280557222

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.