Evidence map›Paper›PMID 35535086›Full record

ArticleJournal of clinical and experimental hepatology

Prevalence and Predictors of Nonalcoholic Fatty Liver Disease in Family Members of Patients With Nonalcoholic Fatty Liver Disease.

Abhinav Anand, Amit A Singh, Anshuman Elhence, Manas Vaishnav, Sagnik Biswas, Deepak Gunjan, Shivanand R Gamanagatti, Baibaswata Nayak, Ramesh Kumar, Shalimar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Abhinav AnandDepartment of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India.
Amit A SinghDepartment of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India.
Anshuman ElhenceDepartment of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India.
Manas VaishnavDepartment of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India.
Sagnik BiswasDepartment of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India.
Deepak GunjanDepartment of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India.
Shivanand R GamanagattiDepartment of Radiology, All India Institute of Medical Sciences, New Delhi, India.
Baibaswata NayakDepartment of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India.
Ramesh KumarDepartment of Gastroenterology, All India Institute of Medical Sciences, Patna, Bihar, India.
ShalimarDepartment of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India.
All India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aims: Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease worldwide. Despite the high prevalence, no screening recommendations yet exist. We designed a prospective observational study to estimate the prevalence of NAFLD in the family of patients with NAFLD and develop a predictive model for identifying it. Methodology: The prevalence of NAFLD in patients' family members was estimated using ultrasonography, and univariate and multivariate odds were calculated for its predictors. A model was created using the significant parameters on multivariate odds, and its performance was tested using the area under the receiver operating characteristic (AUROC). Results: Among 447 family members of 191 patients with NAFLD, the prevalence of NAFLD was 55.9%. Family members with NAFLD were younger and had lower serum levels of aspartate aminotransferase, alanine aminotransferase (ALT), triglycerides. The liver stiffness measurement and controlled attenuation parameter values were also lesser in family members compared to the index cases. Age, body mass index (BMI), and ALT were independent predictors of NAFLD in the family members. A model combining age and BMI had an AUROC of 0.838 [95% confidence interval (CI) 0.800-0.876, Conclusion: Family members of patients with NAFLD are at increased risk of NAFLD. Screening strategies using BMI and age ensure early identification and could be beneficial in clinical practice.

Indexed as

ALT, Alanine aminotransferaseAPRI, AST to platelet ratio indexAST, Aspartate aminotransferaseAUROC, Area under ROCBMIBMI, Body mass indexCAP, Controlled attenuation parameterCI, Confidence intervalEASL, European Association for the Study of the Liverfamily membersFAST, FibroScan-ASTFDRs, First-degree relativesFIB-4, Fibrosis-4HbA1C, Glycosylated hemoglobinHDL-C, High-density lipoprotein-cholesterolLSM, Liver stiffness measureMetS, Metabolic syndromeNAFLD, Non-alcoholic fatty liver diseaseNASH, Non-alcoholic steatohepatitisNCEP-ATP, National Cholesterol Education Program- Adult Treatment PanelNFS, NAFLD fibrosis scorenonalcoholic fatty liver diseaseOR, Odds ratiopredictorsROC, Receiver operating curve

Identifiers

PMID35535086
PMCPMC9077183
OpenAlexW3187359723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.