Evidence map›Paper›PMID 35535085›Full record

ArticleJournal of clinical and experimental hepatology

When Push Comes to Shove! Emergency ABO-Incompatible Pediatric Living Donor Liver Transplant for Acute Wilson's Disease.

Somashekara Hosaagrahara Ramakrishna, Mohan Babu Kasala, Karnan Perumal, Selvakumar Malleeswaran, Rajanikanth V Patcha, Joy Varghese, Malathy Sathiyasekaran, Mettu Srinivas Reddy

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Somashekara Hosaagrahara RamakrishnaDepartment of Pediatric Hepatology, Gleneagles Global Health City, Perumbakkam, Chennai, India.
Mohan Babu KasalaDepartment of Pediatric Intensive Care, Gleneagles Global Health City, Perumbakkam, Chennai, India.
Karnan PerumalDepartment of Pediatric Intensive Care, Gleneagles Global Health City, Perumbakkam, Chennai, India.
Selvakumar MalleeswaranLiver Anesthesia and Critical Care, Gleneagles Global Health City, Perumbakkam, Chennai, India.
Rajanikanth V PatchaDepartment of Liver Transplant and Hepatopancreaticobiliary Surgery, Gleneagles Global Health City, Perumbakkam, Chennai, India.
Joy VargheseDepartment of Hepatology and Liver Transplant, Gleneagles Global Health City, Perumbakkam, Chennai, India.
Malathy SathiyasekaranSenior Pediatric Gastroenterologist, MGM, Rainbow and Kanchi Kamakoti CHILDs Trust Hospitals, Chennai, India.
Mettu Srinivas ReddyDepartment of Liver Transplant and Hepatopancreaticobiliary Surgery, Gleneagles Global Health City, Perumbakkam, Chennai, India.
Global Hospitals · INKanchi Kamakoti CHILDS Trust Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ABO-incompatible living donor liver transplantation (ABOi-LDLT) is on the rise as a viable option in countries with limited access to deceased donor grafts. While reported outcomes of ABOi-LT in children are similar to ABO- Compatible liver transplant (ABOc-LT), most children beyond 1-2 years of age will need desensitization to overcome the immunological barrier of incompatible blood groups. The current standard protocol for desensitization is Rituximab that targets B lymphocytes and is given 2-3 weeks prior to LT. However, this timeline may not be feasible in children requiring emergency LT for acute liver failure (ALF) or acute-on-chronic liver failure (ACLF). In this emergency situation of ABOi-LT, a safe multipronged approach may be an acceptable alternative solution. We report a child with acute Wilson's disease with rapidly deteriorating liver function who underwent a successful ABOi-LDLT using a rapid desensitization protocol.

Indexed as

ABOc-LT, ABO-compatible liver transplantation (ABOi-LDLT)ABOi-LDLT, ABO-incompatible living donor liver transplantationACLF, Acute-on-chronic liver failureacute-on-chronic liver diseaseacute Wilson’s diseaseALF, Acute liver failureAMR, Antibody-mediated rejectionCMV, CytomegalovirusCSF, Cerebrospinal fluidemergency ABOi-LDLTGRWR, Graft-to-recipient weight ratioLDLT, Living donor liver transplantationliving donor liver transplantationLT, Liver transplantMMF, Mycophenolate mofetilPVT, Portal vein thrombosisRituximab

Identifiers

PMID35535085
PMCPMC9077158
OpenAlexW3194394636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.