Evidence map›Paper›PMID 35535073›Full record

ArticleJournal of clinical and experimental hepatology

Tuberculosis in Cirrhosis - A Diagnostic and Management Conundrum.

Saurabh Mishra, Sunil Taneja, Arka De, Valliappan Muthu, Nipun Verma, Madhumita Premkumar, Ajay Duseja, Virendra Singh

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Observational
  3. Anti-Tubercular Drug-Induced Liver Injury: Current Understanding and Emerging Directions.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Management of Portal Hypertension.Journal of clinical and experimental hepatology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Saurabh MishraDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Sunil TanejaDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Arka DeDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Valliappan MuthuDepartment of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Nipun VermaDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Madhumita PremkumarDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Ajay DusejaDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Virendra SinghDepartment of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Diagnosis and management of tuberculosis (TB) in patients with cirrhosis remains challenging. We studied the clinical spectrum, diagnosis, and management of TB along with the assessment of the diagnostic utility of various laboratory investigations in this cohort. Methods: A retrospective review of records of patients with cirrhosis (July 2017 and December 2019) was done. Out of 30 patients with cirrhosis and TB, 20 patients with pleural/peritoneal TB (cases) were compared with 20 consecutively selected spontaneous bacterial peritonitis (SBP) controls. Composite of clinical, laboratory, radiologic features and response to antituberculosis therapy (ATT) was taken as the gold standard to diagnose TB. Results: Extrapulmonary TB (EPTB) (n = 23, 76.7%) was more common. Overall, 9 (30%) patients presented with ATT-induced hepatitis. Patients with pleural/peritoneal TB had less severe hepatic dysfunction as compared to SBP group with significantly lower CTP [8 ± 1.5 vs. 9 ± 1.7 ( Conclusions: EPTB is more frequent in patients with cirrhosis. Relatively lower cutoffs of ascitic/pleural fluid total protein and ADA may be useful to diagnose EPTB in patients with high pretest probability. Individualized ATT with close monitoring and dynamic modifications is effective and well-tolerated.

Indexed as

ADA, Adenosine deaminaseadenosine deaminaseAFB, Acid-fast bacilliAKI, Acute kidney injuryantituberculosis therapyATT, Anti-Tuberculosis therapyAUROC, Area under receiver operator curvechronic liver diseaseCI, Confidence intervalcirrhosisCT, Computed tomographyCTP, Child-Turcotte-PughDILI, Drug-induced liver injuryEPTB, Extrapulmonary TuberculosisLSM, Liver stiffness measurementMELD, Model for End-stage liver diseaseMELD-Na, Model for End-stage liver disease with sodiumMTB, Mycobacterium TuberculosismTB-PCR, multiplex TB-polymerase chain reactionNAAT, Nucleic acid amplification testSAAG, Serum-ascitic albumin gradientSBE, Spontaneous bacterial empyemaSBP, Spontaneous Bacterial PeritonitisSD, Standard deviationSPAG, Serum-pleural fluid albumin gradientTB, TuberculosistuberculosisZN, Ziehl-Neilson

Identifiers

PMID35535073
PMCPMC9077226
OpenAlexW3201418354

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.