Evidence map›Paper›PMID 35534925›Full record

ArticleHypertension (Dallas, Tex. : 1979)2022

Chronic Hypoxia in Ovine Pregnancy Recapitulates Physiological and Molecular Markers of Preeclampsia in the Mother, Placenta, and Offspring.

Wen Tong, Beth J Allison, Kirsty L Brain, Olga V Patey, Youguo Niu, Kimberley J Botting, Sage G Ford, Tessa A Garrud, Peter F B Wooding, Caroline J Shaw and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024
    Guideline
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Determinants of Placental Versus Maternal Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Translatable in-vivo investigation of effects of progressive hypoxia in pregnancy on fetal cardiac structure and function in sheep.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025
    Article
  14. Placental mitochondria in high-altitude pregnancy: metabolic adaptations and a toolkit for respiratory assessment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  15. The uteroplacental circulation at high altitude: adaptation and maladaptation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  16. AMPK function in uterine vasculature and placenta at high altitude.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  17. Fetal growth and congenital heart disease at high altitude.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Wen TongDepartment of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.).ORCID 0000-0003-1647-4166
Beth J AllisonDepartment of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.).ORCID 0000-0002-1060-513X
Kirsty L BrainDepartment of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.).ORCID 0000-0002-5566-7748
Olga V PateyDepartment of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.).
Youguo NiuDepartment of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.).
Kimberley J BottingDepartment of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.).
Sage G FordDepartment of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.).
Tessa A GarrudDepartment of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.).
Peter F B WoodingDepartment of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.).ORCID 0000-0003-2471-7586
Caroline J ShawDepartment of Metabolism, Digestion and Reproduction, Imperial College London, United Kingdom (C.J.S.).ORCID 0000-0002-8002-2976
Qiang LyuDepartment of Aerospace Physiology, Fourth Military Medical University, Xi'an, China (Y.N., Q.L., L.Z., J.M., D.A.G.).
Lin ZhangDepartment of Aerospace Physiology, Fourth Military Medical University, Xi'an, China (Y.N., Q.L., L.Z., J.M., D.A.G.).
Jin MaDepartment of Aerospace Physiology, Fourth Military Medical University, Xi'an, China (Y.N., Q.L., L.Z., J.M., D.A.G.).
Tereza Cindrova-DaviesDepartment of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.).ORCID 0000-0002-9212-0514
Hong Wa YungDepartment of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.).
Graham J BurtonDepartment of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.).ORCID 0000-0001-8677-4143
Dino A GiussaniDepartment of Physiology Development & Neuroscience, University of Cambridge, United Kingdom (W.T., B.J.A., K.L.B., O.V.P., Y.N., K.J.B., S.G.F., T.A.G., P.F.B.W., T.C.-D., H.W.Y., G.J.B., D.A.G.).ORCID 0000-0002-1308-1204
Green Tide Turbines (United Kingdom) · GBAir Force Medical University · CNBritish Heart Foundation · GBImperial College London · GB

Funding

British Heart Foundation RG/11/16/29260British Heart Foundation RG/17/8/32924
6 · The paper itself

Abstract

backgroundPreeclampsia continues to be a prevalent pregnancy complication and underlying mechanisms remain controversial. A common feature of preeclampsia is utero-placenta hypoxia. In contrast to the impact of hypoxia on the placenta and fetus, comparatively little is known about the maternal physiology.

methodsWe adopted an integrative approach to investigate the inter-relationship between chronic hypoxia during pregnancy with maternal, placental, and fetal outcomes, common in preeclampsia. We exploited a novel technique using isobaric hypoxic chambers and in vivo continuous cardiovascular recording technology for measurement of blood pressure in sheep and studied the placental stress in response to hypoxia at cellular and subcellular levels.

resultsChronic hypoxia in ovine pregnancy promoted fetal growth restriction (FGR) with evidence of fetal brain-sparing, increased placental hypoxia-mediated oxidative damage, and activated placental stress response pathways. These changes were linked with dilation of the placental endoplasmic reticulum (ER) cisternae and increased placental expression of the antiangiogenic factors sFlt-1 (soluble fms-like tyrosine kinase 1) and sEng (soluble endoglin), combined with a shift towards an angiogenic imbalance in the maternal circulation. Chronic hypoxia further led to an increase in uteroplacental vascular resistance and the fall in maternal blood pressure with advancing gestation measured in normoxic pregnancy did not occur in hypoxic pregnancy.

conclusionsTherefore, we show in an ovine model of sea-level adverse pregnancy that chronic hypoxia recapitulates physiological and molecular features of preeclampsia in the mother, placenta, and offspring.

Indexed as

Pre-EclampsiaAnimalsBiomarkersFemaleHumansHypoxiaMothersPlacentaPlacenta Growth FactorPregnancySheepVascular Endothelial Growth Factor Receptor-1BiomarkersPlacenta Growth FactorVascular Endothelial Growth Factor Receptor-1endoplasmic reticulumhypoxiaoxidative stressplacentaunfolded protein response

Identifiers

PMID35534925
PMCPMC9172902
OpenAlexW4280535742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.