Evidence map›Paper›PMID 35534871›Full record

ArticleParasites & vectors2022

Infection and seroprevalence of Borrelia persica in domestic cats and dogs in Israel.

Gad Baneth, Ann Dvorkin, Bar Ben-Shitrit, Gabriela Kleinerman, Harold Salant, Reinhard K Straubinger, Yaarit Nachum-Biala

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasites & vectors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

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  8. Molecular characterization ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Gad Baneth *The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, 761001, Rehovot, Israel. gad.baneth@mail.huji.ac.il.ORCID http://orcid.org/0000-0002-7549-1305
Ann Dvorkin *The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, 761001, Rehovot, Israel.
Bar Ben-ShitritThe Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, 761001, Rehovot, Israel.
Gabriela KleinermanThe Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, 761001, Rehovot, Israel.
Harold SalantThe Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, 761001, Rehovot, Israel.
Reinhard K StraubingerBacteriology and Mycology, Institute for Infectious Diseases and Zoonoses, Ludwig-Maximilians-Universität München, Munich, Germany.
Yaarit Nachum-BialaThe Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P.O. Box 12, 761001, Rehovot, Israel.
Hebrew University of Jerusalem · ILLudwig-Maximilians-Universität München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRelapsing fever borreliosis is an infectious disease caused by bacteria of the genus Borrelia, inflicting recurrent episodes of fever and spirochetemia in humans. Borrelia persica, the causative agent of relapsing fever in Israel, is prevalent over a broad geographic area that extends from India to Egypt. It is transmitted by the soft tick Ornithodoros tholozani and causes disease in humans as well as domestic cats and dogs. The goal of this study was to survey domestic dogs and cats in Israel for infection with B. persica.

methodsBlood, sera and demographic and clinical data were collected from dogs and cats brought for veterinary care in central Israel. PCR followed by DNA sequencing was used to detect B. persica DNA in blood samples, and an enzyme-linked immunosorbent assay (ELISA) was used to detect antibodies reactive with B. persica antigens in sera from the same animals. This is the first serological survey of B. persica in dogs and the first survey for antibodies reactive with a relapsing fever Borrelia sp. in cats globally.

resultsFour of the 208 dogs (1.9%) and three of 103 cats (2.9%) sampled were positive by PCR for B. persica DNA, and 24 dogs (11.5%) and 18 cats (17.5%) were seropositive for B. persica antigen by ELISA. The ratio between PCR-positivity and seropositivity in both the dog and cat populations was 1:6. All four PCR-positive dogs and two of three PCR-positive cats were seronegative, suggesting a probable recent infection. Thrombocytopenia showed significant association with seropositivity in dogs (P = 0.003). In cats, anemia had a significant association with seropositivity (P = 0.0001), and thrombocytopenia was associated with the combined prevalence of seropositivity or PCR-positivity (P = 0.022).

conclusionsBorrelia persica infection is more prevalent and widespread in domestic canine and feline populations in Israel than previously thought. Dogs and cats may play a role as reservoirs and sentinels for human infection. Precautions should be taken to prevent transfusion-transmitted infection between blood donor and recipient animals.

Indexed as

BorreliaBorrelia InfectionsCat DiseasesDog DiseasesOrnithodorosRelapsing FeverThrombocytopeniaAnimalsCatsDNADogsIsraelSeroepidemiologic StudiesDNAAnemiaBorrelia persicaCatDogIsraelThrombocytopeniaTick-borne relapsing fever

Identifiers

PMID35534871
PMCPMC9087918
OpenAlexW4229448830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.