Evidence map›Paper›PMID 35534825›Full record

Trial reportBMC anesthesiology2022

Subanaesthetic dose of esketamine during induction delays anaesthesia recovery a randomized, double-blind clinical trial.

Cao Zhang, Jiangqin He, Qinye Shi, Fangping Bao, Jianhong Xu

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Cao ZhangAnaesthesia Department, The Fourth Affiliated Hospital Zhejiang University School of Medicine, No. N1, Shangcheng Road, Yiwu City, Zhejiang Province, 322000, People's Republic of China.
Jiangqin HeAnaesthesia Department, The Fourth Affiliated Hospital Zhejiang University School of Medicine, No. N1, Shangcheng Road, Yiwu City, Zhejiang Province, 322000, People's Republic of China.
Qinye ShiAnaesthesia Department, The Fourth Affiliated Hospital Zhejiang University School of Medicine, No. N1, Shangcheng Road, Yiwu City, Zhejiang Province, 322000, People's Republic of China.
Fangping BaoAnaesthesia Department, The Fourth Affiliated Hospital Zhejiang University School of Medicine, No. N1, Shangcheng Road, Yiwu City, Zhejiang Province, 322000, People's Republic of China.
Jianhong XuAnaesthesia Department, The Fourth Affiliated Hospital Zhejiang University School of Medicine, No. N1, Shangcheng Road, Yiwu City, Zhejiang Province, 322000, People's Republic of China. 1197058@zju.edu.cn.
Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEsketamine is an antagonist of the N-methyl-D-aspartate receptor (NMDA receptor) that is widely used for multimodal analgesia. In addition to analgesia, sedation is another important effect of esketamine. However, data are limited regarding the sedation effect of esketamine during general anaesthesia. The objective of this study was to determine whether sedation with a subanaesthetic does of esketamine affects anaesthesia recovery.

methodsFifty patients, ASA I to II patient scheduled to laparoscopic cholecystectomy, were randomly assigned to receive a single bolus of esketamine 0.2 mg kg-1 (esketamine group) or placebo (control group). Propofol, sufentanil and rocuronium were used during total intravenous anaesthesia. The patients' time of recovery from anaesthesia, postoperative pain, postoperative nausea and vomiting, and postoperative agitation were analysed.

resultsData from 47 patients were analysed. The average time of anaesthetic recovery was 22.04 ± 1.48 min in the esketamine group(n = 23) and 17.54 ± 1.46 min in the control group(n = 24). The recovery time was significantly longer in the esketamine group. Postoperative pain in the PACU was lower in the esketamine group (NRS score range 0-2) than in the control group (NRS score range 0-3). There were no differences in postoperative nausea and vomiting, and postoperative agitation.

conclusionSubanaesthetic doses of esketamine can reduce postoperative pain in the PACU but delay the aesthetic recovery during the laparoscopic cholecystectomy, without affecting postoperative nausea and vomiting, and postoperative agitation.

trial registrationThe study was registered at the Chinese Clinical Trial Registry http://www.chictr.org.cn/ (Registration date: 20/11/2020; TrialID: ChiCTR2000040077 ).

Indexed as

KetaminePostoperative Nausea and VomitingAnesthesia, GeneralDouble-Blind MethodHumansPostoperative PainEsketamineKetamineEsketamineGeneral anaesthetic recoveryPostoperative agitationPostoperative nausea and vomitingPostoperative pain

Identifiers

PMID35534825
PMCPMC9082902
OpenAlexW4229370200

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.