Evidence map›Paper›PMID 35534778›Full record

Trial reportEuropean journal of nutrition2022

Daily supplementation of a multiple micronutrient powder improves folate but not thiamine, riboflavin, or vitamin B

Guy-Marino Hinnouho, Daniela Hampel, Setareh Shahab-Ferdows, Maxwell A Barffour, Liadhan McAnena, Charles D Arnold, K Ryan Wessells, Sengchanh Kounnavong, Lindsay H Allen, Helene McNulty and 1 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02428647 (Lao Zinc Study), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02428647 nacompletednot on this map

Lao Zinc Study: The Effects of Two Forms of Daily Preventive Zinc Supplementation Versus Therapeutic Zinc Supplementation for Diarrhea on Young Children's Physical Growth and Risk of New Episodes of Diarrhea

TypeinterventionalSponsorUniversity of California, DavisRan2015 to 2017Enrolled3,433ConditionsDiarrheaArmsMNP, preventive zinc supplement, therapeutic zinc supplement, preventive placebo supplement, therapeutic placebo supplement
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Guy-Marino HinnouhoDepartment of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA. gmhinnouho@hki.org.ORCID http://orcid.org/0000-0001-8079-9702
Daniela HampelDepartment of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA.
Setareh Shahab-FerdowsUSDA, ARS Western Human Nutrition Research Center, Davis, CA, USA.
Maxwell A BarffourDepartment of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA.
Liadhan McAnenaNutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK.
Charles D ArnoldDepartment of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA.
K Ryan WessellsDepartment of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA.
Sengchanh KounnavongLao Tropical and Public Health Institute, Vientiane, Lao People's Democratic Republic.
Lindsay H AllenDepartment of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA.
Helene McNultyNutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK.
Sonja Y HessDepartment of Nutrition, Institute for Global Nutrition, University of California, Davis, CA, USA.
University of California, Davis · USWestern Human Nutrition Research Center · USUniversity of Ulster · GBHelen Keller International · USMissouri State University · USPublic Health Institute · US

Funding

Bill and Melinda Gates Foundation OPP1134272Nutrition International and the Mathile Institute for the Advancement of Human Nutrition 10-1347-UCALIF-07Thrasher Research Fund 14261
6 · The paper itself

Abstract

purposeTo assess the effects of intervention with a daily multiple micronutrient powder (MNP) on thiamine, riboflavin, folate, and B

methodsChildren (n = 1704) aged 6-23 mo, participating in a double-blind placebo-controlled randomized trial were individually randomized to receive daily either MNP (containing 0.5 mg of thiamine, 0.5 mg riboflavin, 150 μg folic acid, and 0.9 μg vitamin B

resultsThere was no treatment effect on endline eThDP concentrations (110.6 ± 8.9 nmol/L in MNP vs. 109.4 ± 8.9 nmol/L in placebo group; p = 0.924), EGRac (1.46 ± 0.3 vs. 1.49 ± 0.3; p = 0.184) and B

conclusionsCompared to a placebo, daily MNP for 9 months increased only folate but not thiamine, riboflavin, or B

trial registrationThe trial was registered at www. CLINICALTRIALS: gov (NCT02428647) on April 29 2015.

Indexed as

Dietary SupplementsMicronutrientsNutritional StatusChildFolic AcidHumansLaosPowdersRiboflavinThiamineVitamin B 12VitaminsFolic AcidMicronutrientsPowdersRiboflavinThiamineVitamin B 12VitaminsFolateLao PDRMicronutrient powderMNPRiboflavinThiamineVitamin B12Young children

Identifiers

PMID35534778
PMCPMC9464137
OpenAlexW4229459466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.