Evidence map›Paper›PMID 35534769›Full record

ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2022

Trends in postoperative opioid prescribing in Ontario between 2013 and 2019: a population-based cohort study.

Naheed K Jivraj, Karim Ladha, Akash Goel, Andrea Hill, Duminda N Wijeysundera, Brian T Bateman, Hannah Wunsch

Abstract read
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In one paragraph

Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. The role of anesthesiologists in reducing opioid harm.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Naheed K JivrajDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada. naheed.jivraj@mail.utoronto.ca.ORCID http://orcid.org/0000-0002-4005-7015
Karim LadhaDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.
Akash GoelDepartment of Anesthesia and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Andrea HillDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Duminda N WijeysunderaDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.
Brian T BatemanDepartment of Anesthesia, Perioperative, and Pain Medicine, and Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Hannah WunschDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.
St. Michael's Hospital · CAUniversity of Toronto · CABrigham and Women's Hospital · USSunnybrook Health Science Centre · CA

Funding

The Impact of Prescription Opioid Use on Pregnancy OutcomesR01DA044293 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI BATEMAN, BRIAN THOMAS · 2017 to 2020
$2.1M
Acute Pain Management and Long-term Opioid Use after SurgeryR01DA042299 · NIDA · SUNNYBROOK RESEARCH INSTITUTE · PI NEUMAN, MARK DAVID, WUNSCH, HANNAH · 2017 to 2020
$2.0M
NIDA NIH HHS R01 DA042299-01A1NIDA NIH HHS R01 DA044293-01A1
6 · The paper itself

Abstract

purposeMany hospital and provincial-level recommendations now advise a tailored approach to postoperative opioid prescribing; recent trends in postoperative prescribing at the population level have not been well described.

methodsThis population-based cohort study included opioid-naïve patients ≥ 18 yr of age who underwent one of 16 surgical procedures with varying anticipated postoperative pain between July 2013 and March 2020. We evaluated the rate of filled opioid prescriptions within seven days postoperatively, the total morphine milligram equivalent (MME) dose, duration, and type of the first opioid prescription. We then compared the MMEs in initial opioid prescriptions with available procedure-specific recommendations.

resultsThe sample included 900,989 opioid-naïve patients (mean [standard deviation (SD)] age of 50 [17] 31 yr; 66% women). The percentage of patients filling an opioid prescription within 7 days postoperatively increased from 65% in 2013 to 69% in 2016, and returned to the baseline (65%) in 2019. The mean (SD) MMEs dispensed increased until 2015/2016 and then declined (226 [176] MMEs in 2013, 240 [202] MMEs in 2016, and 175 [175] MMEs in 2019). The most frequently prescribed opioid in 2013 was oxycodone compared with hydromorphone in 2019. Among patients who filled an opioid prescription in 2013, 67% were prescribed an opioid dose higher than those in one set of available prescribing recommendations, while in 2019, 41% were prescribed doses above those stated in recommendations.

conclusionWhile the proportion of patients filling an opioid prescription postoperatively remained s during the study period, MMEs decreased after 2016. Opioid prescribing remained significantly higher than available prescribing recommendations, particularly among low pain procedures. These findings highlight the need to identify strategies that improve adherence to surgery-specific prescribing guidelines in North America.

Indexed as

Analgesics, OpioidPractice Patterns, Physicians'Cohort StudiesDrug PrescriptionsFemaleHumansMaleOntarioPostoperative PainRetrospective StudiesAnalgesics, Opioidopioid prescribingphysicianspostoperative painprescription drugssurgery

Identifiers

PMID35534769
OpenAlexW4229453518

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.