Evidence map›Paper›PMID 35534661›Full record

ArticleNeurocritical care2022

Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.

Shraddha Mainali, Venkatesh Aiyagari, Sheila Alexander, Yelena Bodien, Varina Boerwinkle, Melanie Boly, Emery Brown, Jeremy Brown, Jan Claassen, Brian L Edlow and 43 more

Erratum issued Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurocritical care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06426602 (Unlocking Functional Communication for Patients With Disorders of Consciousness With Innovative Brain Computer Interface Technology), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06426602 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Unlocking Functional Communication for Patients With Disorders of Consciousness With Innovative Brain Computer Interface Technology

TypeinterventionalSponsorAmy WagnerRan2024 to 2026Enrolled40ConditionsDisorders of ConsciousnessArmsmindBEAGLE daily device use
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Observational
  5. Review
  6. Article
  7. Review
  8. Disorders of Consciousness Rehabilitation: Ethical Dimensions and Epistemic Dilemmas.Physical medicine and rehabilitation clinics of North America · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Acute Disorders of Consciousness in Pediatric Severe Sepsis and Organ Failure: Secondary Analysis of the Multicenter Phenotyping Sepsis-Induced Multiple Organ Failure Study.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2023
    Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

53 authors.

Shraddha MainaliDepartment of Neurology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. shraddha.mainali@vcuhealth.org.ORCID http://orcid.org/0000-0002-9495-3843
Venkatesh AiyagariNeurological Surgery and Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sheila AlexanderSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Yelena BodienDepartment of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Charlestown, MA, USA.
Varina BoerwinkleDivision of Neurology, Barrow Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA.
Melanie BolyDepartments of Neurology and Psychiatry, Wisconsin Institute for Sleep and Consciousness, University of Wisconsin, Madison, WI, USA.
Emery BrownDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jeremy BrownOffice of Emergency Care Research, Division of Clinical Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Jan ClaassenDepartment of Neurology, Columbia University Medical Center, New York Presbyterian Hospital, New York, NY, USA.
Brian L EdlowDepartment of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA, USA.
Ericka L FinkDepartment of Critical Care Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Joseph J FinsDivision of Medical Ethics, Weill Cornell Medical College, New York, NY, USA.
Brandon ForemanDivision of Neurocritical Care, Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA.
Jennifer FronteraDepartment of Neurology, New York University School of Medicine, New York, NY, USA.
Romergryko G GeocadinDivision of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Joseph GiacinoHarvard Medical School, Spaulding Rehabilitation Hospital, Boston, MA, USA.
Emily J GilmoreComprehensive Epilepsy Center, Department of Neurology, Yale University, New Haven, CT, USA.
Olivia GosseriesComa Science Group, GIGA Consciousness, University of Liege, Liege, Belgium.
Flora HammondIndiana University Department of Physical Medicine and Rehabilitation, University of Indiana School of Medicine, Indianapolis, IN, USA.
Raimund HelbokDepartment of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
J Claude HemphillDepartment of Neurology, University of California, San Francisco, CA, USA.
Karen HirschDivision of Neurocritical Care, Department of Neurology, Stanford University, Stanford, CA, USA.
Keri KimCollege of Pharmacy, University of Illinois, Chicago, IL, USA.
Steven LaureysComa Science Group, Cyclotron Research Center, University of Liege, Liege, Belgium.
Ariane LewisDepartment of Neurology and Neurosurgery, New York University Langone Health, New York, NY, USA.
Geoffrey LingDivision of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sarah L LivesayDepartment of Adult Health and Gerontological Nursing, College of Nursing, Rush University, Chicago, IL, USA.
Victoria McCredieInterdepartmental Division of Critical Care, Department of Respirology, University of Toronto, Toronto, ON, Canada.
Molly McNettCollege of Nursing, Ohio State University, Columbus, OH, USA.
David MenonDivision of Anaesthesia, University of Cambridge, Cambridge, UK.
Erika MolteniSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
DaiWai OlsonNeuroscience Intensive Care Unit, O'Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kristine O'PhelanDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Soojin ParkDepartment of Neurology and Neurocritical Care, Columbia University, New York, NY, USA.
Len PolizzottoDepartment of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.
Jose Javier ProvencioDepartment of Neurology and Neuroscience, University of Virginia, Charlottesville, VA, USA.
Louis PuybassetDepartment of Neuroradiology, University of Paris VI, Pierre et Marie Curie, Pitié-Salpêtrière Hospital, Paris, France.
Chethan P Venkatasubba RaoDivision of Vascular Neurology and Neurocritical Care, CHI St. Luke's Health-Baylor St. Luke's Medical Center, Baylor College of Medicine, Houston, TX, USA.
Courtney RobertsonDepartments of Anesthesiology and Critical Care Medicine, and Pediatrics, Johns Hopkins Children's Center, The Johns Hopkins University School of Medcine, Baltimore, MD, USA.
Benjamin RohautNeuroscience Intensive Care Unit, Department of Neurology, Sorbonne University, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.
Michael RubinNeurological Surgery and Neurology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Tarek SharsharDepartment of Intensive Care, Paris Descartes University, Paris, France.
Lori ShutterUniversity of Pittsburgh, Pittsburgh, PA, USA.
Gisele Sampaio SilvaHospital Israelita Albert Einstein, Academic Research Organization and Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil.
Wade SmithDepartment of Neurology, University of California, San Francisco, CA, USA.
Robert D StevensDivision of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Aurore ThibautComa Science Group, GIGA Consciousness, University of Liege, Liege, Belgium.
Paul VespaRonald Reagan UCLA Medical Center, UCLA Santa Monica Medical Center, Santa Monica, CA, USA.
Amy K WagnerDepartment of Physical Medicine and Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Wendy C ZiaiDivision of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Elizabeth ZinkDepartment of Neuroscience Nursing, The Johns Hopkins Hospital, The Johns Hopkins University, Baltimore, MD, USA.
Jose I SuarezDivision of Neurosciences Critical Care, Departments of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Curing Coma Campaign collaborators

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
RECONFIG - REcovery of CONsciousness Following Intracerebral hemorrhaGeR01NS106014 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLAASSEN, JAN · 2019 to 2023
$3.6M
BAsIC - Brain-computer-interface practical Application in the Intensive Care unit: a pilot studyR03NS112760 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLAASSEN, JAN · 2019 to 2020
$162k
NCATS NIH HHS UL1 TR001863NINDS NIH HHS R01 NS106014NINDS NIH HHS R03 NS112760
6 · The paper itself

Abstract

This proceedings article presents actionable research targets on the basis of the presentations and discussions at the 2nd Curing Coma National Institutes of Health (NIH) symposium held from May 3 to May 5, 2021. Here, we summarize the background, research priorities, panel discussions, and deliverables discussed during the symposium across six major domains related to disorders of consciousness. The six domains include (1) Biology of Coma, (2) Coma Database, (3) Neuroprognostication, (4) Care of Comatose Patients, (5) Early Clinical Trials, and (6) Long-term Recovery. Following the 1st Curing Coma NIH virtual symposium held on September 9 to September 10, 2020, six workgroups, each consisting of field experts in respective domains, were formed and tasked with identifying gaps and developing key priorities and deliverables to advance the mission of the Curing Coma Campaign. The highly interactive and inspiring presentations and panel discussions during the 3-day virtual NIH symposium identified several action items for the Curing Coma Campaign mission, which we summarize in this article.

Indexed as

ComaConsciousnessConsciousness DisordersHumansNational Institutes of Health (U.S.)United StatesComaCuring Coma CampaignDisorders of consciousnessNational Institute of HealthProceedings

Identifiers

PMID35534661
PMCPMC9283342

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.