Evidence map›Paper›PMID 35534633›Full record

ArticleNature methods2022

Understudied proteins: opportunities and challenges for functional proteomics.

Georg Kustatscher, Tom Collins, Anne-Claude Gingras, Tiannan Guo, Henning Hermjakob, Trey Ideker, Kathryn S Lilley, Emma Lundberg, Edward M Marcotte, Markus Ralser and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. A Forward Genetic Screen inbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Single-Injection Multi-Omics Analysis by Direct Infusion Mass Spectrometry.Angewandte Chemie (International ed. in English) · 2026
    Article
  8. Artificial Intelligence Powers Protein Functional Annotation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Georg KustatscherInstitute of Quantitative Biology, Biochemistry and Biotechnology, University of Edinburgh, Edinburgh, UK. georg.kustatscher@ed.ac.uk.ORCID http://orcid.org/0000-0001-8955-0866
Tom CollinsWellcome Trust, London, UK.
Anne-Claude GingrasLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health System, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-6090-4437
Tiannan GuoZhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.ORCID http://orcid.org/0000-0003-3869-7651
Henning HermjakobEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.ORCID http://orcid.org/0000-0001-8479-0262
Trey IdekerDivision of Genetics, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Kathryn S LilleyCambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-0594-6543
Emma LundbergScience for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH-Royal Institute of Technology, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7034-0850
Edward M MarcotteDepartment of Molecular Biosciences, Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0001-8808-180X
Markus RalserDepartment of Biochemistry, Charité University Medicine, Berlin, Germany.
Juri RappsilberBioanalytics, Technische Universität Berlin, Berlin, Germany. juri.rappsilber@tu-berlin.de.ORCID http://orcid.org/0000-0001-5999-1310

Funding

Medical Research Council MR/T03050X/1Wellcome Trust 203149
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ProteinsProteomicsMass SpectrometryProteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.