Evidence map›Paper›PMID 35534575›Full record

ArticleNature biomedical engineering2022

An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid.

Farshad Tehrani, Hazhir Teymourian, Brian Wuerstle, Jonathan Kavner, Ravi Patel, Allison Furmidge, Reza Aghavali, Hamed Hosseini-Toudeshki, Christopher Brown, Fangyu Zhang and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed, 2 pooled it
42.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

214 citing papers in PubMed, 2 syntheses or guidelines pooled it, 554 citations in OpenAlex.

  1. Pooled it
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  9. Design, Construction, and Application of Implantable Fiber Biosensors.Advanced materials (Deerfield Beach, Fla.) · 2026
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  17. A Hitchhiker's Guide to Physical and Cognitive Effort.Sports medicine (Auckland, N.Z.) · 2026
    Review
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  20. Article

154 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Farshad Tehrani *Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Hazhir Teymourian *Department of Nanoengineering, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0025-4732
Brian Wuerstle *Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA.
Jonathan Kavner *Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Ravi PatelDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA.
Allison FurmidgeDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Reza AghavaliDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Hamed Hosseini-ToudeshkiDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Christopher BrownDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA.
Fangyu ZhangDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Kuldeep MahatoDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Zhengxing LiDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Abbas BarfidokhtDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Lu YinDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Paul WarrenDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA.
Nickey HuangDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Zina PatelDepartment of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Patrick P MercierDepartment of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA. pmercier@eng.ucsd.edu.ORCID http://orcid.org/0000-0003-1488-5076
Joseph WangDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, USA. josephwang@eng.ucsd.edu.ORCID http://orcid.org/0000-0002-4921-9674
University of California San Diego · US

Funding

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R21 NS114764 - 01A1
6 · The paper itself

Abstract

Implementations of wearable microneedle-based arrays of sensors for the monitoring of multiple biomarkers in interstitial fluid have lacked system integration and evidence of robust analytical performance. Here we report the development and testing of a fully integrated wearable array of microneedles for the wireless and continuous real-time sensing of two metabolites (lactate and glucose, or alcohol and glucose) in the interstitial fluid of volunteers performing common daily activities. The device works with a custom smartphone app for data capture and visualization, comprises reusable electronics and a disposable microneedle array, and is optimized for system integration, cost-effective fabrication via advanced micromachining, easier assembly, biocompatibility, pain-free skin penetration and enhanced sensitivity. Single-analyte and dual-analyte measurements correlated well with the corresponding gold-standard measurements in blood or breath. Further validation of the technology in large populations with concurrent validation of sensor readouts through centralized laboratory tests should determine the robustness and utility of real-time simultaneous monitoring of several biomarkers in interstitial fluid.

Indexed as

Biosensing TechniquesWearable Electronic DevicesBiomarkersExtracellular FluidGlucoseHumansBiomarkersGlucose

Identifiers

PMID35534575
OpenAlexW4229456303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.