Evidence map›Paper›PMID 35534562›Full record

ArticleNature genetics2022

Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities.

Abrar Choudhury, Stephen T Magill, Charlotte D Eaton, Briana C Prager, William C Chen, Martha A Cady, Kyounghee Seo, Calixto-Hope G Lucas, Tim J Casey-Clyde, Harish N Vasudevan and 26 more

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In one paragraph

Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed, 8 pooled it
42.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

208 citing papers in PubMed, 8 syntheses or guidelines pooled it, 282 citations in OpenAlex.

  1. Pooled it
  2. WHO grade 3 pediatric meningioma: a systematic review of clinical features and patient-level analysis of prognostic factors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
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  14. FFPE-CUTAC: A Single Assay, Multiple Layers.bioRxiv : the preprint server for biology · 2026
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148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 7 institutions in 4 countries.

Abrar ChoudhuryDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8312-2457
Stephen T Magill *Department of Neurological Surgery, Northwestern University, Chicago, IL, USA. stephen.magill@northwestern.edu.ORCID http://orcid.org/0000-0002-5257-7835
Charlotte D Eaton *Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.
Briana C PragerDepartment of Medicine, University of California, San Diego, San Diego, CA, USA.
William C ChenDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.
Martha A CadyDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.
Kyounghee SeoDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.
Calixto-Hope G LucasDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8347-9592
Tim J Casey-ClydeDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9281-4073
Harish N VasudevanDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.
S John LiuDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1042-0191
Javier E Villanueva-MeyerDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Tai-Chung LamDepartment of Clinical Oncology, The University of Hong Kong, Pokfulam, Hong Kong.
Jenny Kan-Suen PuDivision of Neurosurgery, Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong.
Lai-Fung LiDivision of Neurosurgery, Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong.ORCID http://orcid.org/0000-0001-6566-3815
Gilberto Ka-Kit LeungDivision of Neurosurgery, Department of Surgery, The University of Hong Kong, Pokfulam, Hong Kong.
Danielle L SwaneyJ. David Gladstone Institutes, California Institute for Quantitative Biosciences, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6119-6084
Michael Y ZhangDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.
Jason W ChanDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.
Zhixin QiuDepartment of Medicine, University of California, San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-7103-8004
Michael V MartinDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Matthew S SuskoDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.
Steve E BraunsteinDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.
Nancy Ann Oberheim BushDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Jessica D SchulteDepartment of Neurosciences, University of California, San Diego, San Diego, CA, USA.
Nicholas ButowskiDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Penny K SneedDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA.
Mitchel S BergerDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Nevan J KroganJ. David Gladstone Institutes, California Institute for Quantitative Biosciences, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-4902-337X
Arie PerryDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8300-7261
Joanna J PhillipsDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3789-8120
David A SolomonDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-4571-7999
Joseph F CostelloDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3189-584X
Michael W McDermottDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Jeremy N RichDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. drjeremyrich@gmail.com.ORCID http://orcid.org/0000-0001-7845-5302
David R RaleighDepartment of Radiation Oncology, University of California, San Francisco, San Francisco, CA, USA. david.raleigh@ucsf.edu.ORCID http://orcid.org/0000-0001-9299-8864
University of California, San Francisco · USUniversity of California San Diego · USUniversity of Hong Kong · HKQB3 · USNorthwestern University · USQueen Mary Hospital · CNUniversity of Pittsburgh · US

Funding

Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Susan M Chang · 2002 to 2026
$57.4M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
Using Networks to Seed Hierarchical Whole-cell Models of CancerU54CA209891 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI IDEKER, TREY, KROGAN, NEVAN J · 2017 to 2021
$10.9M
Understanding druggable drivers of meningioma tumorigenesisR01CA262311 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RALEIGH, DAVID R · 2021 to 2025
$2.7M
Investigating the Regulation and Role of FOXM1 in Aggressive MeningiomaF30CA246808 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOUDHURY, ABRAR · 2020 to 2023
$159k
Development of a molecular diagnostic and prognostic signature for meningiomaF32CA213944 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAGILL, STEPHEN T · 2017 to 2017
$63k
NCI NIH HHS F30 CA246808NCI NIH HHS F32 CA213944NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA262311NCI NIH HHS U54 CA209891NIGMS NIH HHS T32 GM007618
6 · The paper itself

Abstract

Meningiomas are the most common primary intracranial tumors. There are no effective medical therapies for meningioma patients, and new treatments have been encumbered by limited understanding of meningioma biology. Here, we use DNA methylation profiling on 565 meningiomas integrated with genetic, transcriptomic, biochemical, proteomic and single-cell approaches to show meningiomas are composed of three DNA methylation groups with distinct clinical outcomes, biological drivers and therapeutic vulnerabilities. Merlin-intact meningiomas (34%) have the best outcomes and are distinguished by NF2/Merlin regulation of susceptibility to cytotoxic therapy. Immune-enriched meningiomas (38%) have intermediate outcomes and are distinguished by immune infiltration, HLA expression and lymphatic vessels. Hypermitotic meningiomas (28%) have the worst outcomes and are distinguished by convergent genetic and epigenetic mechanisms driving the cell cycle and resistance to cytotoxic therapy. To translate these findings into clinical practice, we show cytostatic cell cycle inhibitors attenuate meningioma growth in cell culture, organoids, xenografts and patients.

Indexed as

Meningeal NeoplasmsMeningiomaDNA MethylationHumansNeurofibromin 2ProteomicsNeurofibromin 2

Identifiers

PMID35534562
PMCPMC9374001
OpenAlexW4229449309

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.