ArticleNature genetics2022
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects.
Abstract read
In one paragraph
Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 233 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
233citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
233 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Socioeconomic position, genetic susceptibility, and epigenetic profiles in obesity across the life course: a systematic review.International journal of obesity (2005) · 2026Pooled it
- Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes.Nature human behaviour · 2025Pooled it
- Overcoming attenuation bias in regressions using polygenic indices.Nature communications · 2023Pooled it
- No genome-wide correlations and little shared genetic architecture between reproductive life-history traits and estrogen receptor-positive breast cancer risk.Molecular biology and evolution · 2026Article
- Genetics of major depressive disorder in a homogeneous population with uniform phenotyping.Molecular psychiatry · 2026Article
- Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Multivariate GWAS framework for family trios with parental phenotypes to control dynastic effects.BMC bioinformatics · 2026Article
- Heritability and social interaction in labor market outcomes: Evidence from the population of twins in the United States.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genomic insights into natural selection in recent human history.Nature reviews. Genetics · 2026Review
- Article
- Article
- Genetic architectures of brain-related traits are shaped by strong selective constraints.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Association Between Socioeconomic Status and Atrial Fibrillation: A Two-Sample Mendelian Randomization Study.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Article
- Beyond years of schooling: Genetic associations across educational milestones in two Norwegian cohorts.PLoS genetics · 2026Article
- Plasma apolipoprotein E protein attenuates pulmonary fibrosis through LRP1 and PLAU dual receptor-mediated TGF-β/Smad inhibition.Journal of advanced research · 2026Article
- "Yet the Problem Remains": Why Genetic Determinism Still Haunts Biomedical Research.Bioethics · 2026Article
- Common and rare genetic variant associations with cognitive performance across development in British birth cohorts.Nature human behaviour · 2026Article
- Investigating antidiabetic drug targets as potential therapeutic modulators for schizophrenia.Psychopharmacology · 2026Article
- Genetic Assessment of Oesophageal Safety of GLP-1 and GIP Receptor Perturbation: A Drug-Target Mendelian Randomisation Study.Biomedicines · 2026Article
173 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
102 authors.
Laurence J HoweMedical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. laurence.howe@bristol.ac.uk.ORCID http://orcid.org/0000-0002-2819-9686
Michel G NivardDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-2015-1888
Tim T MorrisMedical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0001-8178-6815
Ailin F HansenK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Humaira RasheedMedical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-3331-5864
Yoonsu ChoMedical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0001-6118-6652
Geetha ChittoorDepartment of Population Health Sciences, Geisinger Health, Danville, PA, USA.
Rafael AhlskogDepartment of Government, Uppsala University, Uppsala, Sweden.
Penelope A LindPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID http://orcid.org/0000-0002-3887-2598
Teemu PalviainenInstitute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-7847-8384
Matthijs D van der ZeeDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-4076-9167
Rosa CheesmanPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2167-7470
Yunzhang WangDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1165-3595
Shuai LiCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Lucija KlaricMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0003-3105-8929
Scott M RatliffDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3443-8030
Marianne NygaardThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0003-0703-2665
Alexandros GiannelisDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-4587-0336
Emily A WilloughbyDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-7559-1544
Chandra A ReynoldsDepartment of Psychology, University of California, Riverside, Riverside, CA, USA.ORCID http://orcid.org/0000-0001-6502-7173
Jared V BalbonaDepartment of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.ORCID http://orcid.org/0000-0003-4466-248X
Ole A AndreassenNORMENT Centre, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Helga AskDepartment of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0003-0149-5319
Aris BarasRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-6830-3396
Christopher R BauerBioMarin Pharmaceutical Inc., Novato, CA, USA.
Dorret I BoomsmaDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-7099-7972
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0198-5078
Harry CampbellCentre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.
Zhengming ChenNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-6423-105X
Paraskevi ChristofidouDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Elizabeth CorfieldDepartment of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-0119-157X
Christina C DahmDepartment of Public Health, Aarhus University, Aarhus, Denmark.
Deepika R DokuruDepartment of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.
Luke M EvansInstitute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.ORCID http://orcid.org/0000-0002-7458-1720
Eco J C de GeusDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands.
Sudheer GiddaluruInstitute of Health and Society, University of Oslo, Oslo, Norway.
Scott D GordonDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-7623-328X
K Paige HardenDepartment of Psychology and Population Research Center, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0002-1557-6737
W David HillLothian Birth Cohorts Group, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Amanda HughesMedical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0001-5896-7650
Shona M KerrMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-4137-1495
Yongkang KimInstitute for Behavioral Genetics, University of Colorado at Boulder, Boulder, CO, USA.
Hyeokmoon KweonDepartment of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-3649-0457
Antti LatvalaInstitute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.
Deborah A LawlorMedical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-6793-2262
Liming LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Kuang LinNuffield Department of Population Health, University of Oxford, Oxford, UK.
Per MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Skøyen, Oslo, Norway.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7315-7899
Travis T MallardDepartment of Psychology and Population Research Center, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0002-3265-3001
Pekka MartikainenPopulation Research Unit, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-9374-1438
Melinda C MillsLeverhulme Centre for Demographic Science, University of Oxford, Oxford, UK.
Pål Rasmus NjølstadDepartment of Clinical Science, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0003-0304-6728
John D OvertonRegeneron Genetics Center, Tarrytown, NY, USA.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
David J PorteousCentre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1249-6106
Jeffrey ReidRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-8645-4713
Karri SilventoinenPopulation Research Unit, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.
Melissa C SoutheyPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0002-6313-9005
Camilla StoltenbergNorwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-8747-1985
Elliot M Tucker-DrobDepartment of Psychology and Population Research Center, University of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0001-5599-6237
Margaret J WrightQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0001-7133-4970
Social Science Genetic Association Consortium
Within Family Consortium
John K HewittDepartment of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.
Matthew C KellerDepartment of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.ORCID http://orcid.org/0000-0002-6075-9882
Michael C StallingsDepartment of Psychology & Neuroscience, University of Colorado at Boulder, Boulder, CO, USA.
James J LeeDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-6547-5128
Kaare ChristensenThe Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark.ORCID http://orcid.org/0000-0002-5429-5292
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-9717-8459
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3575-5468
James F WilsonMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5751-9178
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Sara HäggDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-2452-1500
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9795-0365
Jean-Baptiste PingaultSocial Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Robert PlominSocial Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-0756-3629
Alexandra HavdahlPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-9268-0423
Meike BartelsDepartment of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-9667-7555
Nicholas G MartinDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Sven OskarssonDepartment of Government, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-8698-2866
Anne E JusticeDepartment of Population Health Sciences, Geisinger Health, Danville, PA, USA.
Iona Y MillwoodNuffield Department of Population Health, University of Oxford, Oxford, UK.
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Øyvind NaessInstitute of Health and Society, University of Oslo, Oslo, Norway.
Cristen J WillerK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0001-5645-4966
Bjørn Olav ÅsvoldK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0003-3837-2101
Philipp D KoellingerDepartment of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-7413-0412
Jaakko KaprioInstitute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3716-2455
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Robin G WaltersNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-9179-0321
Daniel J BenjaminUCLA Anderson School of Management, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2642-5416
Patrick TurleyCenter for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
David M EvansMedical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0003-0663-4621
George Davey SmithMedical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.ORCID http://orcid.org/0000-0002-1407-8314
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9405-9550
Ben Brumpton *Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. ben.brumpton@ntnu.no.ORCID http://orcid.org/0000-0002-3058-1059
Gibran Hemani *Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. g.hemani@bristol.ac.uk.ORCID http://orcid.org/0000-0003-0920-1055
Neil M Davies *Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. neil.davies@bristol.ac.uk.ORCID http://orcid.org/0000-0002-2460-0508
Funding
Using genetics to discover mechanisms of myocardial infarctionR01HL109946 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YUQING Eugene CHEN, Ida Liisa Surakka · 2011 to 2026
$8.9MScientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI MARK D. HAYWARD · 2017 to 2026
$5.2MGenome-Wide Analyses of Health and Well-Being PhenotypesR01AG042568 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENJAMIN, DANIEL J · 2015 to 2021
$2.8MInfrastructure and Core Activities of the Social Science Genetic Association ConsortiumR24AG065184 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENJAMIN, DANIEL J · 2019 to 2023
$1.8MGenome-Wide Analyses of Health and Well-Being PhenotypesR56AG042568 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENJAMIN, DANIEL J · 2018 to 2018
$803kMedical Research Council MC_PC_13049Medical Research Council MC_PC_14135Medical Research Council MC_U137686851Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_00017/1Medical Research Council MC_UU_12026/2Medical Research Council MR/R026408/1Medical Research Council MR/T030852/1NHLBI NIH HHS R01 HL109946NIA NIH HHS R01 AG042568NIA NIH HHS R24 AG065184NIA NIH HHS R56 AG042568NICHD NIH HHS P2C HD042849Wellcome Trust 208806/Z/17/ZWellcome Trust 212946/Z/18/Z
Abstract
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic and indirect genetic effects, but large-scale family datasets have been lacking. We combined data from 178,086 siblings from 19 cohorts to generate population (between-family) and within-sibship (within-family) GWAS estimates for 25 phenotypes. Within-sibship GWAS estimates were smaller than population estimates for height, educational attainment, age at first birth, number of children, cognitive ability, depressive symptoms and smoking. Some differences were observed in downstream SNP heritability, genetic correlations and Mendelian randomization analyses. For example, the within-sibship genetic correlation between educational attainment and body mass index attenuated towards zero. In contrast, analyses of most molecular phenotypes (for example, low-density lipoprotein-cholesterol) were generally consistent. We also found within-sibship evidence of polygenic adaptation on taller height. Here, we illustrate the importance of family-based GWAS data for phenotypes influenced by demographic and indirect genetic effects.
Indexed as
Genome-Wide Association StudyPolymorphism, Single NucleotideHumansMendelian Randomization AnalysisMultifactorial InheritancePhenotype
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.