Evidence map›Paper›PMID 35534377›Full record

ReviewTrends in parasitology2022

Plasmodium's fight for survival: escaping elimination while acquiring nutrients.

Erin A Schroeder, Michael E Chirgwin, Emily R Derbyshire

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in parasitology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. The role of autophagy in protozoan infections.Frontiers in cellular and infection microbiology · 2026
    Review
  4. Review
  5. Article
  6. mSphere · 2024
    Article
  7. iScience · 2024
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Erin A SchroederDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Michael E ChirgwinDepartment of Chemistry, Duke University, Durham, NC, USA.
Emily R DerbyshireDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA; Department of Chemistry, Duke University, Durham, NC, USA. Electronic address: Emily.Derbyshire@duke.edu.
Duke University · US

Funding

Enabling Host Processes for Defense Against Liver Stage Malaria InfectionDP2AI138239 · NIAID · DUKE UNIVERSITY · PI DERBYSHIRE, EMILY R · 2017 to 2017
$2.3M
NIAID NIH HHS DP2 AI138239
6 · The paper itself

Abstract

Plasmodium parasites extensively alter their host hepatocyte to evade host detection and support an unprecedented replication rate. Host cell manipulation includes association with the host early and late endomembrane systems, where Plasmodium accesses nutrients while suppressing cellular immune processes. Early endomembrane organelles provide an opportunity to sequester an abundance of lipids and proteins, but the association with late endomembrane organelles also risks autophagy-mediated elimination. While not all parasites survive, those that do benefit from a plethora of nutrients provided through this pathway. In this review, we discuss recent advances in our understanding of how Plasmodium parasites balance the need for host nutrients while avoiding elimination during the liver stage.

Indexed as

ParasitesPlasmodiumAnimalsHepatocytesLiverNutrientsNutrientsautophagyendomembranehepatocytelipidsmalariaPlasmodium

Identifiers

PMID35534377
PMCPMC9187605
OpenAlexW4229065533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.