Evidence map›Paper›PMID 35534340›Full record

ArticleTrends in neurosciences2022

Midbrain cholinergic neurons signal negative feedback to promote behavioral flexibility.

Nadine K Gut, Juan Mena-Segovia

Open access · greenAbstract readComment
In one paragraph

Article in Trends in neurosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nadine K GutCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA.
Juan Mena-SegoviaCenter for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA. Electronic address: juan.mena@rutgers.edu.
Rutgers, The State University of New Jersey · US

Funding

Cholinergic brainstem signaling in striatal circuitsR01NS100824 · NINDS · RUTGERS THE STATE UNIV OF NJ NEWARK · PI MENA-SEGOVIA, JUAN · 2017 to 2021
$1.7M
NINDS NIH HHS R01 NS100824
6 · The paper itself

Abstract

Cholinergic neurons of the pedunculopontine nucleus (PPN) are relevant for adaptive behavior. In a recent study, Ruan et al. revealed that PPN cholinergic neurons signal negative feedback during reward omission after contingency changes, which is necessary for switching to new behavioral strategies.

Indexed as

Cholinergic NeuronsPedunculopontine Tegmental NucleusFeedbackHumansMesencephalonRewardacetylcholinepedunculopontinereversal learning

Identifiers

PMID35534340
PMCPMC9635055
OpenAlexW4229332072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.