Evidence map›Paper›PMID 35534310›Full record

Trial reportVaccine2022

Association of Anti-Rotavirus IgA Seroconversion with Growth, Environmental Enteric Dysfunction and Enteropathogens in Rural Pakistani Infants.

Sheraz Ahmed, Junaid Iqbal, Kamran Sadiq, Fayaz Umrani, Arjumand Rizvi, Furqan Kabir, Zehra Jamil, Sana Syed, Lubaina Ehsan, Fatima Zulqarnain and 9 more

Registry-linked trialOpen access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Vaccine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03588013 (Study of Environmental Enteropathy and Malnutrition in Pakistan), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03588013 nacompletednot on this map

Study of Environmental Enteropathy and Malnutrition in Pakistan

TypeinterventionalSponsorAga Khan UniversityRan2016 to 2019Enrolled416ConditionsMalnutrition, Child, Enteropathy, Vaccine Response Impaired, StuntingArmsNutritional education, Ready to Use Therapeutic Food, Upper gastrointestinal endoscopy with biopsy
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 3 countries.

Sheraz AhmedDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan; Institute for Global Health, University of Siena, Italy. Electronic address: sheraz.ahmed@aku.edu.
Junaid IqbalDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan; Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan. Electronic address: junaid.iqbal@aku.edu.
Kamran SadiqDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: kamran.sadiq@aku.edu.
Fayaz UmraniDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: fayaz.umrani@aku.edu.
Arjumand RizviDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: arjumand.rizvi@aku.edu.
Furqan KabirDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: furqan.kabir@aku.edu.
Zehra JamilDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Virginia, Charlottesville, USA. Electronic address: zehra.jamil@aku.edu.
Sana SyedDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Virginia, Charlottesville, USA. Electronic address: sana.syed@virginia.edu.
Lubaina EhsanDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Virginia, Charlottesville, USA. Electronic address: lubaina.ehsan@gmail.com.
Fatima ZulqarnainDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Virginia, Charlottesville, USA. Electronic address: ecq2gq@hscmail.mcc.virginia.edu.
Muhammed SajidDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: sajid.muhammad@aku.edu.
Aneeta HotwaniDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: aneeta.hotwani@aku.edu.
Najeeb RahmanDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: najeeb.rahman@aku.edu.
Jennie Z MaDepartment of Public Health Sciences, University of Virginia, Charlottesville, USA. Electronic address: jzm4h@virginia.edu.
Monica McNealDivision of Infectious Diseases, Department of Pediatrics, University of Cincinnati College of Medicine, OH, USA. Electronic address: monica.mcneal@cchmc.edu.
Sue Ann Costa ClemensInstitute for Global Health, University of Siena, Italy. Electronic address: sue.costa@unisi.it.
Najeeha Talat IqbalDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: najeeha.iqbal@aku.edu.
Sean R MooreDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Virginia, Charlottesville, USA. Electronic address: sean.moore@virginia.edu.
Asad AliDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan. Electronic address: asad.ali@aku.edu.
Aga Khan University · PKUniversity of Virginia · USUniversity of Siena · ITUniversity of Cincinnati Medical Center · US

Funding

Pediatric Infectious Diseases, Enteric Health and Malnutrition in Pakistan (PIDEMP) Research Training ProgramD43TW007585 · FIC · AGA KHAN UNIVERSITY (PAKISTAN) · PI ALI, SYED ASAD, MOORE, SEAN RYAN · 2006 to 2024
$3.7M
FIC NIH HHS D43 TW007585
6 · The paper itself

Abstract

backgroundThe underperformance of oral vaccines in children of low- and middle-income countries is partly attributable to underlying environmental enteric dysfunction (EED). METHODOLOGY: We conducted a longitudinal, community-based study to evaluate the association of oral rotavirus vaccine (Rotarix®) seroconversion with growth anthropometrics, EED biomarkers and intestinal enteropathogens in Pakistani infants. Children were enrolled between three to six months of their age based on their nutritional status. We measured serum anti-rotavirus immunoglobulin A (IgA) at enrollment and nine months of age with EED biomarkers and intestinal enteropathogens.

resultsA total of 391 infants received two doses of rotavirus (RV) vaccine. 331/391 provided paired blood samples. Of these 331 children, 45% seroconverted at 9 months of age, 35% did not seroconvert and 20% were seropositive at baseline. Non-seroconverted children were more likely to be stunted, wasted and underweight at enrollment. In univariate analysis, insulin-like growth factor (IGF) concentration at 6 months were higher in seroconverters, median (25th, 75th percentile): 26.3 (16.5, 43.5) ng/ml vs. 22.5 (13.6, 36.3) ng/ml for non-seroconverters, p-value = 0.024. At nine months, fecal myeloperoxidase (MPO) concentrations were significantly lower in seroconverters, 3050(1250, 7587) ng/ml vs. 4623.3 (2189, 11650) ng/ml in non-seroconverted children, p-value = 0.017. In multivariable logistic regression analysis, alpha-1 acid glycoprotein (AGP) and IGF-1 concentrations were positively associated with seroconversion at six months. The presence of sapovirus and rotavirus in fecal samples at the time of rotavirus administration, was associated with non-seroconversion and seroconversion, respectively.

conclusionWe detected high baseline RV seropositivity and impaired RV vaccine immunogenicity in this high-risk group of children. Healthy growth, serum IGF-1 and AGP, and fecal shedding of rotavirus were positively associated with RV IgA seroconversion following immunization, whereas the presence of sapovirus was more common in non-seroconverters.

trial registrationClinical Trials ID: NCT03588013.

Indexed as

RotavirusRotavirus InfectionsRotavirus VaccinesAntibodies, ViralBiomarkersChildHumansImmunoglobulin AInfantInsulin-Like Growth Factor IPakistanSeroconversionVaccines, AttenuatedAntibodies, ViralBiomarkersImmunoglobulin AInsulin-Like Growth Factor IRotavirus VaccinesVaccines, AttenuatedBiomarkersEnvironmental enteric dysfunctionInfantsMalnutritionOral vaccinesRotavirus vaccineStunting

Identifiers

PMID35534310
PMCPMC9168439
OpenAlexW4229062734

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.