Evidence map›Paper›PMID 35534093›Full record

Observational studyOpen heart2022

Evaluating the role of transthoracic echocardiography in hospitalised patients with COVID-19 infection.

Aswin Babu, Zhaoyi Meng, Nadia Eden, Daniel Lamb, Jan Nouza, Raghav Bhatia, Irina Chis Ster, Jonathan Bennett, Victor Voon

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Open heart, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
  2. Article
  3. Observational
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Aswin BabuCardiology Department, Homerton University Hospital, London, UK aswin.babu1@nhs.net.ORCID 0000-0001-6066-7972
Zhaoyi MengCardiology Department, Homerton University Hospital, London, UK.
Nadia EdenCardiology Department, Homerton University Hospital, London, UK.
Daniel LambCardiology Department, Homerton University Hospital, London, UK.
Jan NouzaCardiology Department, Homerton University Hospital, London, UK.
Raghav BhatiaDepartment of Cardiology, St George's University of London, London, UK.
Irina Chis SterInstitute of Infection and Immunity, St George's University of London, London, UK.
Jonathan BennettDepartment of Cardiology, Queen Elizabeth Hospital, London, UK.
Victor VoonCardiology Department, Homerton University Hospital, London, UK.
Homerton University Hospital · GBSt George's, University of London · GBQueen Elizabeth Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify the most common transthoracic echocardiogram (TTE) parameters in patients hospitalised with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/COVID-19) and their association with myocardial injury and outcomes.

methodsA retrospective, single-centre, observational, exploratory cohort study was performed at the height of the COVID-19 pandemic. All SARS-CoV-2 polymerase chain reaction (PCR) positive patients who underwent a TTE during their inpatient admission between 1 March 2020 and 31 October 2020 were analysed. The most frequent cardiovascular risk factor profile and echocardiographic features were investigated.

resultsA total of 87 patients met the eligibility criteria. A salient 41.4% (n=36) of our cohort succumbed to this devastating virus. More than half of our hospital population (58.6%) were admitted to the intensive care unit (ITU) and this was significantly associated with inpatient mortality (OR: 7.14, CI 2.53 to 20.19, p<0.001). Hypertension was the most common cardiovascular risk factor (51.7%) with no additional prominence in non-survivors (OR: 2.33, CI 0.97 to 5.61, p=0.059). Remarkably, 90.8% of our cohort demonstrated a preserved left ventricular ejection fraction, although 69.1% had elevated troponin levels. Only 1 patient (1.1%) was given a diagnostic label of myocarditis. A raised pulmonary artery systolic pressure (36.8%) andright ventricle (RV) dysfunction (26.4%) were the most common echocardiographic features. In particular, the presence of RV dysfunction was significantly related to adverse outcomes (OR: 2.97, CI 1.11 to 7.94, p<0.03).

conclusionsIn this cohort of extremely unwell patients hospitalised with COVID-19 pneumonitis, the presence of RV dysfunction or admission to ITU was significantly associated with inpatient case fatality ratio. Moreover, COVID-19-induced myocarditis remains extremely rare.

Indexed as

COVID-19MyocarditisCohort StudiesEchocardiographyHumansPandemicsRetrospective StudiesSARS-CoV-2Stroke VolumeVentricular Function, LeftCOVID-19Diagnostic ImagingEchocardiographyHypertension

Identifiers

PMID35534093
PMCPMC9086279
OpenAlexW4280511382

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.