Evidence map›Paper›PMID 35534080›Full record

ArticleBMJ open2022

Medication use in populations exposed to the 2010 Eyjafjallajökull eruption: an interrupted time series analysis.

Rebekka Björg Guðmundsdóttir, Brynjólfur Gauti Guðrúnar Jónsson, Unnur Valdimarsdottir, Hanne Krage Carlsen, Heidrun Hlodversdottir, Huan Song, Edda Bjork Thordardottir, Guðrún Pétursdóttir, Haraldur Briem, Thorarinn Gislason and 4 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 4 countries.

Rebekka Björg GuðmundsdóttirCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, School of Health Sciences, Reykjavik, Iceland rebekkabg@hi.is.ORCID 0000-0003-1551-8462
Brynjólfur Gauti Guðrúnar JónssonCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, School of Health Sciences, Reykjavik, Iceland.ORCID 0000-0003-4730-5584
Unnur ValdimarsdottirCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, School of Health Sciences, Reykjavik, Iceland.ORCID 0000-0001-5382-946X
Hanne Krage CarlsenEnvironment and Natural Resources, University of Iceland, School of Health Sciences, Reykjavik, Iceland.ORCID 0000-0003-1656-9624
Heidrun HlodversdottirFaculty of Medicine, University of Iceland, School of Health Sciences, Reykjavik, Iceland.
Huan SongCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, School of Health Sciences, Reykjavik, Iceland.
Edda Bjork ThordardottirCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, School of Health Sciences, Reykjavik, Iceland.
Guðrún PétursdóttirInstitute for Sustainability Studies, University of Iceland, Reykjavik, Iceland.
Haraldur BriemCentre for Health Threats and Communicable Diseases, Directorate of Health, Chief Epidemiologis, Reykjavik, Iceland.
Thorarinn GislasonFaculty of Medicine, University of Iceland, School of Health Sciences, Reykjavik, Iceland.
Thorolfur GudnasonCentre for Health Threats and Communicable Diseases, Directorate of Health, Chief Epidemiologis, Reykjavik, Iceland.
Thröstur ThorsteinssonEnvironment and Natural Resources, University of Iceland, School of Health Sciences, Reykjavik, Iceland.
Helga Zoega *Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, School of Health Sciences, Reykjavik, Iceland.ORCID 0000-0003-0761-9028
Arna Hauksdóttir *Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, School of Health Sciences, Reykjavik, Iceland.ORCID 0000-0002-4253-1059
University of Iceland · ISDirectorate of Health · IS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the trends in medication use indicative of physical and psychological morbidity following the 2010 volcanic eruption in Eyjafjallajökull immediately after and during a 3-year period following the eruption.

designPopulation-based register study.

settingEyjafjallajökull eruption in Iceland, 2007-2013.

participantsAll residents in Iceland who received at least one medication dispensing were identified. Residents of exposed areas were classified into exposure groups (individual-level data) and residents in other parts of Iceland were included as a non-exposed group (aggregated data). INTERVENTION/EXPOSURE: Eyjafjallajökull erupted on 14 April 2010 and continued for 39 days, producing heavy ash fall in South Iceland.

main outcome measuresUsing interrupted time series analysis, we examined annual and quarterly changes in medicine use, measured as number of dispensed defined daily dose (DDD) per 1000 individuals. We calculated the level shift (immediate change) and change in slope from pre-eruption to post-eruption (long-term change) in medication dispensing.

resultsAmong exposed residents, there was a 6% decrease (95% CI -7% to -4%) in the annual number of dispensed DDDs 1-year post-eruption in the overall medication class, including analgesics (-5%, 95% CI -6% to -3%), hypnotics and sedatives (-9%, 95% CI -11% to -7%) and respiratory medications (-7%, 95% CI -9% to -5%; -8%, 95% CI -11% to -4%). Simultaneously, there was a 9% decrease (95% CI -14% to -4%) in the overall medication class among non-exposed residents. Moreover, among exposed residents, we observed change in slope of -4% (95% CI -7% to -1%) in the overall medication class, including for analgesics (-6%, 95% CI -8% to -3%) and other respiratory drugs (-10%, 95% CI -16% to -4%).

conclusionOur findings indicate that the eruption did not lead to increases in medication dispensing among residents of exposed areas, rather decreases for some medicine classes. The results should be interpreted with caution since the content of each eruption differs.

Indexed as

Volcanic EruptionsHumansIcelandInterrupted Time Series AnalysisMorbidityTimeepidemiologymental healthpublic health

Identifiers

PMID35534080
PMCPMC9086619
OpenAlexW4280497086

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.