SynthesisBMJ open gastroenterology2022
Heyde's syndrome: a systematic review of case reports.
Synthesis in BMJ open gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Effectiveness of aortic valve replacement in Heyde syndrome: a meta-analysis.European heart journal · 2023Pooled it
- Concomitant acquired and inherited von Willebrand disease: A challenging bleeding disorder.Transfusion · 2026Article
- Heyde Syndrome in Moderate Bioprosthetic Aortic Valve Stenosis: A Twist in the Valve.JACC. Case reports · 2026Article
- An Uncommon Presentation of Heyde Syndrome: Absence of Visible Endoscopic Angiodysplasia With Resolution After Transcatheter Aortic Valve Replacement.The American journal of case reports · 2026Article
- Heyde syndrome secondary to hypertrophic obstructive cardiomyopathy: a case report.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026Article
- Heyde Syndrome: A Literature Review.Health science reports · 2026Article
- Aortic Bioprosthetic Stenosis Leading to Heyde Syndrome.JACC. Case reports · 2025Article
- Heyde's Syndrome: Presentation and Successful Treatment With Transcatheter Aortic Valve Implantation (TAVI).Cureus · 2025Article
- Management challenges in Heyde syndrome: A case report of recurrent gastrointestinal bleeding and aortic stenosis in an octogenarian.Global cardiology science & practice · 2025Article
- Article
- Gastric Antral Vascular Ectasia Syndrome With Aortic Stenosis: A Twist on Heyde Syndrome?Journal of medical cases · 2025Article
- Bleeding due to a Broken Heart Valve: Heyde's Syndrome Secondary to Severe Mitral Regurgitation.Gastro hep advances · 2025Article
- Heyde Syndrome Unveiled: A Case Report with Current Literature Review and Molecular Insights.International journal of molecular sciences · 2024Review
- Gastrointestinal Angiodysplasia Resolution After Transcatheter Aortic Valve Implantation.JAMA network open · 2024Article
- Persistent Gastrointestinal Bleeding after Aortic Valve Replacement in Heyde's Syndrome.Journal of clinical medicine · 2024Review
- Two Cases With Recurrent Challenges: Unraveling the Complexity of Heyde Syndrome With Rebleeding.Cureus · 2024Article
- Evidence That Anemia Accelerates AS Progression Via Shear-Induced TGF-β1 Activation: Heyde's Syndrome Comes Full Circle.JACC. Basic to translational science · 2024Article
- Gastrointestinal bleeding associated to aortic valve stenosis (Heyde's syndrome): a case series and literature review.European heart journal. Case reports · 2023Article
- Beyond Acquired Von Willebrand Deficiency: Exploring Alternative Mechanisms of Heyde's Syndrome.Cureus · 2023Article
- Cecal Dieulafoy lesion is a rare cause of lower gastrointestinal bleeding: A case report.SAGE open medical case reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHeyde's syndrome (HS), a rare condition characterised by a unique relationship between severe aortic stenosis and angiodysplasia, is often diagnosed late increasing the risk for a prolonged hospital course and mortality in the elderly. The leading hypothesis explaining the aetiology of HS is acquired von Willebrand syndrome (AVWS) but not all studies support this claim. While individual cases of HS have been reported, here we present the first systematic review of case reports and focus on the prevalence of AVWS.
designA systematic search was conducted through PubMed/MEDLINE, CINAHL-EBSCO, Web of Science and Google Scholar since inception. The resulting articles were screened by two independent reviewers based on inclusion criteria that the article must be a case report/series or a letter to the editor in English describing HS in an adult patient.
resultsSeventy-four articles encompassing 77 cases met the inclusion criteria. The average age was 74.3±9.3 years old with a slight female predominance. The small intestine, especially the jejunum, was the most common location for bleeding origin. Capsule endoscopy and double balloon enteroscopy were superior at identifying bleeding sources than colonoscopy (p=0.0027 and p=0.0095, respectively) and oesophagogastroduodenoscopy (p=0.0006 and p=0.0036, respectively). The mean duration from symptom onset to diagnosis/treatment of HS was 23.8±39 months. Only 27/77 cases provided evidence for AVWS. Surgical and transcutaneous aortic valve replacement (AVR) were superior at preventing rebleeding than non-AVR modalities (p<0.0001).
conclusionFurther research is warranted for a stronger understanding and increased awareness of HS, which may hasten diagnosis and optimal management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.