ArticleStudies in history and philosophy of science2022
Three legs of the missing heritability problem.
Article in Studies in history and philosophy of science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- Which RJournal of human genetics · 2026Article
- Explicitly modeling genetic ancestry to improve polygenic prediction accuracy for height in a large, admixed cohort of US Latinos: Findings from HCHS/SOL.HGG advances · 2026Article
- Ethical Priorities Among Commercial Genomics Professionals : Survey Evidence Highlighting Diversity, Fragmented Privacy Law, and Human Rights Risks as Central Participant Concerns.Journal of bioethical inquiry · 2026Article
- No Argument with Biology? The Effects of Genetic Explanations for Socioeconomic Outcomes on American and Swedish Citizens' Attitudes Towards Government Intervention.Behavior genetics · 2026Article
- Personality Genomics.Annual review of psychology · 2026Review
- Reconceptualizing bipolar disorder through an integrative biological lens: synthesis, convergence, and emerging directions.Frontiers in integrative neuroscience · 2026Review
- Review
- Clustering of lymphoid neoplasms by cell of origin, somatic mutation and drug usage profiles: a multi-trait genome-wide association study.Blood cancer journal · 2025Article
- BIGFAM - variance components analysis from relatives without genotype.Nature communications · 2025Article
- Genomics and psychiatric nosology: avoiding hype, maintaining hope.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- A mathematical framework for the quantitative analysis of genetic buffering.PLoS genetics · 2025Article
- Uncovering hidden factors of cognitive resilience in Alzheimer's disease using a conditional-Gaussian mixture variational autoencoder.NPJ dementia · 2025Article
- Roles for epigenetics in wood formation and stress response intrees-from basic biology to forest management.Frontiers in epigenetics and epigenomics · 2025Review
- Transcripts of splicing factors with time-varying associations with survival outcomes in colorectal cancer.American journal of cancer research · 2025Article
- Shared Genetic Architecture Between COVID-19 Severity and Alzheimer's Disease Across European and African Ancestries.Research square · 2024Article
- The Geneticization of Education and Its Bioethical Implications.Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees · 2024Article
- How to Diagnose Abhorrent Science.The Hastings Center report · 2024Article
- Multi-ancestry Genome-Wide Association Meta-Analysis Identifies Novel Loci in Atopic Dermatitis.medRxiv : the preprint server for health sciences · 2024Article
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Abstract
The so-called 'missing heritability problem' is often characterized by behavior geneticists as a numerical discrepancy between alternative kinds of heritability. For example, while 'traditional heritability' derived from twin and family studies indicates that approximately ∼50% of variation in intelligence is attributable to genetics, 'SNP heritability' derived from genome-wide association studies indicates that only ∼10% of variation in intelligence is attributable to genetics. This 40% gap in variance accounted for by alternative kinds of heritability is frequently referred to as what's "missing." Philosophers have picked up on this reading, suggesting that "dissolving" the missing heritability problem is merely a matter of closing the numerical gap between traditional and molecular kinds of heritability. We argue that this framing of the problem undervalues the severity of the many challenges to scientific understanding of the "heritability" of human behavior. On our view, resolving the numerical discrepancies between alternative kinds of heritability will do little to advance scientific explanation and understanding of behavior genetics. Thus, we propose a new conceptual framework of the missing heritability problem that comprises three independent methodological and explanatory challenges: the numerical gap, the prediction gap, and the mechanism gap.
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