ArticleDiabetes2022
Predictive Metabolomic Markers in Early to Mid-pregnancy for Gestational Diabetes Mellitus: A Prospective Test and Validation Study.
Article in Diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 37 citations in OpenAlex.
- Dietary Strawberries Improve Serum Metabolites of Cardiometabolic Risks in Adults with Features of the Metabolic Syndrome in a Randomized Controlled Crossover Trial.International journal of molecular sciences · 2023Trial
- Early pregnancy metabolomic signatures for child growth trajectories: a prospective metabolome-wide association study.The American journal of clinical nutrition · 2026Article
- A three-metabolite microbiota-associated signature for early risk stratification of gestational diabetes mellitus.Cardiovascular diabetology · 2026Article
- Gestational diabetes mellitus and maternal-infant microbiome axis: mechanistic insights and therapeutic interventions.Journal of translational medicine · 2026Review
- Metabolomics reveals early pregnancy serum metabolic changes and predictive biomarkers in gestational diabetes mellitus.Nutrition & metabolism · 2026Article
- Machine Learning-Based Early Prediction of Gestational Diabetes Using First-Trimester Laboratory Parameters.Cureus · 2026Article
- Comprehensive first-trimester targeted metabolomics for early prediction and understanding of GDM pathophysiology.Frontiers in molecular biosciences · 2026Article
- Early pregnancy meal tolerance test responses and their association with later insulin sensitivity in overweight and obese women: an exploratory analysis.Frontiers in endocrinology · 2026Observational
- Metabolomics of saliva, serum, and urine for pathogenesis, diagnosis, and prognosis in gestational diabetes mellitus.Nature communications · 2025Article
- NMR-based clinical metabolomics for predictive screening of gestational diabetes mellitus (GDM) during the first trimester: a pilot study on North Indian population.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Integration of localized microbiome, metabolome, and clinical datasets predicts healing in chronic wounds among veterans.bioRxiv : the preprint server for biology · 2025Article
- Artificial Intelligence in Gestational Diabetes Care: A Systematic Review.Journal of diabetes science and technology · 2025Review
- Article
- Review
- Metabolomic profiling reveals early biomarkers of gestational diabetes mellitus and associated hepatic steatosis.Cardiovascular diabetology · 2025Article
- Modeling the relative response factor of small molecules in positive electrospray ionization.RSC advances · 2024Article
- Titanium exposure and gestational diabetes mellitus: associations and potential mediation by perturbation of amino acids in early pregnancy.Environmental health : a global access science source · 2024Article
- Biochemical Markers in the Prediction of Pregnancy Outcome in Gestational Diabetes Mellitus.Medicina (Kaunas, Lithuania) · 2024Article
- Combined Exposures and Mixtures Research: An Enduring NIEHS Priority.Environmental health perspectives · 2024Article
- Advanced Mass Spectrometry-Based Biomarker Identification for Metabolomics of Diabetes Mellitus and Its Complications.Molecules (Basel, Switzerland) · 2024Review
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7 authors at 2 institutions in 1 country.
Funding
Abstract
Gestational diabetes mellitus (GDM) predisposes pregnant individuals to perinatal complications and long-term diabetes and cardiovascular diseases. We developed and validated metabolomic markers for GDM in a prospective test-validation study. In a case-control sample within the PETALS cohort (GDM n = 91 and non-GDM n = 180; discovery set), a random PETALS subsample (GDM n = 42 and non-GDM n = 372; validation set 1), and a case-control sample within the GLOW trial (GDM n = 35 and non-GDM n = 70; validation set 2), fasting serum untargeted metabolomics were measured by gas chromatography/time-of-flight mass spectrometry. Multivariate enrichment analysis examined associations between metabolites and GDM. Ten-fold cross-validated LASSO regression identified predictive metabolomic markers at gestational weeks (GW) 10-13 and 16-19 for GDM. Purinone metabolites at GW 10-13 and 16-19 and amino acids, amino alcohols, hexoses, indoles, and pyrimidine metabolites at GW 16-19 were positively associated with GDM risk (false discovery rate <0.05). A 17-metabolite panel at GW 10-13 outperformed the model using conventional risk factors, including fasting glycemia (area under the curve: discovery 0.871 vs. 0.742, validation 1 0.869 vs. 0.731, and validation 2 0.972 vs. 0.742; P < 0.01). Similar results were observed with a 13-metabolite panel at GW 17-19. Dysmetabolism is present early in pregnancy among individuals progressing to GDM. Multimetabolite panels in early pregnancy can predict GDM risk beyond conventional risk factors.
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