Evidence map›Paper›PMID 35532237›Full record

ArticleAntimicrobial agents and chemotherapy2022

Distribution of Common and Rare Genetic Markers of Second-Line-Injectable-Drug Resistance in Mycobacterium tuberculosis Revealed by a Genome-Wide Association Study.

Derek Conkle-Gutierrez, Calvin Kim, Sarah M Ramirez-Busby, Samuel J Modlin, Mikael Mansjö, Jim Werngren, Leen Rigouts, Sven E Hoffner, Faramarz Valafar

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Rapid screening of mutations for second-line-drug-resistant genes in Mycobacterium tuberculosis culture isolates by in-house developed DNA bio-chip.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Derek Conkle-GutierrezLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence (LPCDRP), Biomedical Informatics Research Center, Division of Epidemiology, School of Public Health, San Diego State Universitygrid.263081.e, San Diego, California, USA.ORCID 0000-0002-3442-8334
Calvin KimLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence (LPCDRP), Biomedical Informatics Research Center, Division of Epidemiology, School of Public Health, San Diego State Universitygrid.263081.e, San Diego, California, USA.
Sarah M Ramirez-BusbyLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence (LPCDRP), Biomedical Informatics Research Center, Division of Epidemiology, School of Public Health, San Diego State Universitygrid.263081.e, San Diego, California, USA.
Samuel J ModlinLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence (LPCDRP), Biomedical Informatics Research Center, Division of Epidemiology, School of Public Health, San Diego State Universitygrid.263081.e, San Diego, California, USA.ORCID 0000-0002-7674-305X
Mikael MansjöDepartment of Microbiology, Public Health Agency of Swedengrid.419734.c, Solna, Sweden.
Jim WerngrenDepartment of Microbiology, Public Health Agency of Swedengrid.419734.c, Solna, Sweden.
Leen RigoutsDepartment of Biomedical Sciences, Antwerp University (UA), Antwerp, Belgium.
Sven E HoffnerLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence (LPCDRP), Biomedical Informatics Research Center, Division of Epidemiology, School of Public Health, San Diego State Universitygrid.263081.e, San Diego, California, USA.
Faramarz ValafarLaboratory for Pathogenesis of Clinical Drug Resistance and Persistence (LPCDRP), Biomedical Informatics Research Center, Division of Epidemiology, School of Public Health, San Diego State Universitygrid.263081.e, San Diego, California, USA.ORCID 0000-0002-3648-9384
San Diego State University · USPublic Health Agency of Sweden · SEUniversity of Antwerp · BE

Funding

Evolutionary and Functional Significance of Novel Mutations in MDR-XDR TBR01AI105185 · NIAID · SAN DIEGO STATE UNIVERSITY · PI VALAFAR, FARAMARZ · 2013 to 2021
$5.3M
Undetected Drug resistance and Tolerance in lesions of recurrent TBR01AI163202 · NIAID · SAN DIEGO STATE UNIVERSITY · PI VALAFAR, FARAMARZ · 2022 to 2025
$2.8M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI105185NIAID NIH HHS R01 AI105185NIAID NIH HHS R01 AI163202
6 · The paper itself

Abstract

Point mutations in the

Indexed as

Drug Resistance, Multiple, BacterialMycobacterium tuberculosisAmikacinAntitubercular AgentsCapreomycinGenetic MarkersGenome-Wide Association StudyKanamycinMicrobial Sensitivity TestsMutationAmikacinAntitubercular AgentsCapreomycinGenetic MarkersKanamycinamikacincapreomycindrug resistanceinjectableskanamycinMycobacterium tuberculosisrare mechanismssecond-line antibiotics

Identifiers

PMID35532237
PMCPMC9211393
OpenAlexW4229363540

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.