Evidence map›Paper›PMID 35531590›Full record

ArticleInternational journal of cancer2022

Diagnostic potential of nanoparticle aided assays for MUC16 and MUC1 glycovariants in ovarian cancer.

Shruti Jain, Nimrah Nadeem, Benjamin Ulfenborg, Maria Mäkelä, Shamima Afrin Ruma, Joonas Terävä, Kaisa Huhtinen, Janne Leivo, Björg Kristjansdottir, Kim Pettersson and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in International journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Screening and prevention of ovarian cancer.The Medical journal of Australia · 2024
    Review
  9. Article
  10. Molecular Biomarkers for the Early Detection of Ovarian Cancer.International journal of molecular sciences · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Shruti JainDepartment of Life Technologies and FICAN West Cancer Centre, University of Turku, Turku, Finland.ORCID 0000-0003-0748-6050
Nimrah NadeemDepartment of Life Technologies and FICAN West Cancer Centre, University of Turku, Turku, Finland.
Benjamin UlfenborgSystems Biology Research Centre, School of Bioscience, University of Skövde, Skövde, Sweden.
Maria MäkeläDepartment of Life Technologies and FICAN West Cancer Centre, University of Turku, Turku, Finland.
Shamima Afrin RumaDepartment of Life Technologies and FICAN West Cancer Centre, University of Turku, Turku, Finland.
Joonas TeräväDepartment of Life Technologies and FICAN West Cancer Centre, University of Turku, Turku, Finland.ORCID 0000-0002-2251-5588
Kaisa HuhtinenInstitute of Biomedicine and FICAN West Cancer Centre, University of Turku and Turku University Hospital, Turku, Finland.
Janne LeivoDepartment of Life Technologies and FICAN West Cancer Centre, University of Turku, Turku, Finland.ORCID 0000-0002-1032-6667
Björg KristjansdottirDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden.
Kim PetterssonDepartment of Life Technologies and FICAN West Cancer Centre, University of Turku, Turku, Finland.
Karin SundfeldtDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-7135-3132
Kamlesh GidwaniDepartment of Life Technologies and FICAN West Cancer Centre, University of Turku, Turku, Finland.ORCID 0000-0002-9014-0618
University of Turku · FISahlgrenska University Hospital · SEUniversity of Helsinki · FIUniversity of Skövde · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our study reports the discovery and evaluation of nanoparticle aided sensitive assays for glycovariants of MUC16 and MUC1 in a unique collection of paired ovarian cyst fluids and serum samples obtained at or prior to surgery for ovarian carcinoma suspicion. Selected glycovariants and the immunoassays for CA125, CA15-3 and HE4 were compared and validated in 347 cyst fluid and serum samples. Whereas CA125 and CA15-3 performed poorly in cyst fluid to separate carcinoma and controls, four glycovariants including MUC16

Indexed as

NanoparticlesOvarian NeoplasmsBiomarkers, TumorCA-125 AntigenCarcinoma, Ovarian EpithelialFemaleHumansMembrane ProteinsMucin-1MucinsBiomarkers, TumorCA-125 AntigenMembrane ProteinsMUC16 protein, humanMUC1 protein, humanMucin-1Mucinsdiagnosisepithelial ovarian cancereuropium nanoparticlemucinsSTn

Identifiers

PMID35531590
PMCPMC9546485
OpenAlexW4229369066

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.