ArticleRSC advances2019
Synthesis and bioevaluation of thienopyrimidines bearing a pyrazoline unit as selective PI3Kα inhibitors.
Luogen Lai, Qinqin Wang, Binliang Zhang, Zhen Xiao, Zunhua Yang, Qi Yang, Zixin Luo, Wufu Zhu, Shan Xu
Open access · goldAbstract read
In one paragraphArticle in RSC advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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1 · What the graph read from itWhat it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors at 2 institutions in 1 country.
Luogen LaiJiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University Nanchang 330013 China zhuwufu-1122@163.com shanxu9891@126.com +86 791 8380-2393 +86 791 8380-2393.
Qinqin WangJiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University Nanchang 330013 China zhuwufu-1122@163.com shanxu9891@126.com +86 791 8380-2393 +86 791 8380-2393.
Binliang ZhangJiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University Nanchang 330013 China zhuwufu-1122@163.com shanxu9891@126.com +86 791 8380-2393 +86 791 8380-2393.
Zhen XiaoJiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University Nanchang 330013 China zhuwufu-1122@163.com shanxu9891@126.com +86 791 8380-2393 +86 791 8380-2393.
Zunhua YangCollege of Pharmacy, Jiangxi University of Traditional Chinese Medicine Nanchang 330004 China.
Qi YangJiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University Nanchang 330013 China zhuwufu-1122@163.com shanxu9891@126.com +86 791 8380-2393 +86 791 8380-2393.
Zixin LuoJiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University Nanchang 330013 China zhuwufu-1122@163.com shanxu9891@126.com +86 791 8380-2393 +86 791 8380-2393.
Wufu ZhuJiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University Nanchang 330013 China zhuwufu-1122@163.com shanxu9891@126.com +86 791 8380-2393 +86 791 8380-2393.ORCID https://orcid.org/0000-0001-6075-0450 Shan XuJiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University Nanchang 330013 China zhuwufu-1122@163.com shanxu9891@126.com +86 791 8380-2393 +86 791 8380-2393.
Jiangxi Science and Technology Normal University · CNJiangxi University of Traditional Chinese Medicine · CN
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
A series of thienopyrimidines containing a pyrazoline unit (4a-d, 7a-d and 13a-l) were designed and synthesized. The target compounds were evaluated for antiproliferative activity against A549, HepG2 and MCF-7 cancer cell lines. Among the twenty target compounds, most of them exhibited excellent antiproliferative activity against one or several cancer cell lines. Compound 13f showed the best activity against A549, MCF-7 and HepG2 cancer cell lines, with IC
Identifiers
PMID35531514
PMCPMC9072010
OpenAlexW2973555272
What OpenQuestion holds
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LicenceCC BY
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