Evidence map›Paper›PMID 35531468›Full record

ArticleInternational journal of nephrology2022

Course of Hyperkalemia in Patients on Hemodialysis.

Bruce Spinowitz, Steven Fishbane, Masafumi Fukagawa, Martin Ford, Nicolas Guzman, Anjay Rastogi

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in International journal of nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03303521 (A Phase 3b, Multicenter, Prospective, Randomized, Double Blind, Placebocontrolled Study to Reduce Incidence of Pre-dialysis Hyperkalemia With Sodium Zirconium Cyclosilicate), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03303521 phase3completednot on this map

A Phase 3b, Multicenter, Prospective, Randomized, Double Blind, Placebocontrolled Study to Reduce Incidence of Pre-dialysis Hyperkalemia With Sodium Zirconium Cyclosilicate (DIALIZE)

TypeinterventionalSponsorAstraZenecaRan2017 to 2018Enrolled196ConditionsHyperkalemiaArmsPlacebo, Sodium Zirconium Cyclosilicate (ZS)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 3 countries.

Bruce SpinowitzDepartment of Medicine, NewYork-Presbyterian Queens, Queens, NY, USA.ORCID https://orcid.org/0000-0003-1122-0490
Steven FishbaneDepartment of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, USA.ORCID https://orcid.org/0000-0002-2238-8574
Masafumi FukagawaDivision of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.ORCID https://orcid.org/0000-0002-7832-2339
Martin FordDepartment of Renal Medicine, King's College Hospital NHS Trust, London, UK.ORCID https://orcid.org/0000-0003-4926-3189
Nicolas GuzmanGlobal Medicines Development, AstraZeneca BioPharmaceuticals Research and Development, Gaithersburg, MD, USA.ORCID https://orcid.org/0000-0002-9503-0530
Anjay RastogiUCLA CORE Kidney Program, University of California Los Angeles, Los Angeles, CA, USA.ORCID https://orcid.org/0000-0002-8117-6010
AstraZeneca (United States) · USDonald & Barbara Zucker School of Medicine at Hofstra/Northwell · USKing's College London · GBNew York Hospital Queens · USTokai University · JPUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Evidence of longitudinal serum potassium (sK Objective: These post hoc analyses of the placebo arm of the phase 3b DIALIZE study (NCT03303521) explored the course of hyperkalemia in hemodialysis patients receiving placebo. Methods: In DIALIZE, 196 patients receiving hemodialysis three times weekly were randomized to placebo or sodium zirconium cyclosilicate 5 g starting dose once daily on nondialysis days for 8 weeks. In these post hoc analyses of placebo patients overall ( Results: In placebo patients, the mean predialysis sK Conclusions: Patients receiving placebo and hemodialysis maintained high predialysis sK

Identifiers

PMID35531468
PMCPMC9071981
OpenAlexW4225156890

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.