Evidence map›Paper›PMID 35531376›Full record

ArticleOpen forum infectious diseases2022

Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission.

Katharine A Relph, Clark D Russell, Cameron J Fairfield, Lance Turtle, Thushan I de Silva, Matthew K Siggins, Thomas M Drake, Ryan S Thwaites, Simon Abrams, Shona C Moore and 9 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Observational
  4. Article
  5. Review
  6. Pharmacist-Led Antimicrobial Stewardship and Antibiotic Use in Hospitalized Patients With COVID-19.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. A Perfect Storm: COVID-19 and Antimicrobial Resistance.EMJ. Microbiology & infectious diseases · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 1 country.

Katharine A RelphUniversity of Edinburgh Centre for Inflammation Research, Edinburgh, United Kingdom.
Clark D RussellUniversity of Edinburgh Centre for Inflammation Research, Edinburgh, United Kingdom.ORCID https://orcid.org/0000-0002-9873-8243
Cameron J FairfieldCentre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
Lance TurtleNational Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.ORCID https://orcid.org/0000-0002-0778-1693
Thushan I de SilvaSouth Yorkshire Regional Department of Infection and Tropical Medicine, Sheffield Teaching Hospitals National Health Service Foundation Trust, Sheffield, United Kingdom.
Matthew K SigginsNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Thomas M DrakeCentre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
Ryan S ThwaitesNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Simon AbramsDepartment of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, United Kingdom.
Shona C MooreNational Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.
Hayley E HardwickNational Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.
Wilna OosthuyzenDivision of Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.
Ewen M HarrisonCentre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
Annemarie B DochertyCentre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, United Kingdom.
Peter J M OpenshawNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
J Kenneth BaillieDivision of Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom.
Malcolm G SempleNational Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom.ORCID https://orcid.org/0000-0001-9700-0418
Antonia HoMedical Research Council-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.ORCID https://orcid.org/0000-0003-1465-3785
International Severe Acute Respiratory and Emerging Infections Consortium Coronavirus Clinical Characterisation Consortium (ISARIC4C) Investigators
Centre for Inflammation Research · GBUniversity of Liverpool · GBUniversity of Edinburgh · GBImperial College London · GBRoslin Institute · GBNational Health Service · GBMRC University of Glasgow Centre for Virus Research · GB

Funding

Medical Research Council MC_PC_19025Medical Research Council MC_PC_19026Medical Research Council MC_PC_19059Medical Research Council MR/S032304/1Wellcome Trust 205228/Z/16/Z
6 · The paper itself

Abstract

Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Health Organization Clinical Characterisation Protocol UK study). Although procalcitonin was higher in bacterial coinfection, this was neither clinically significant (median [IQR], 0.33 [0.11-1.70] ng/mL vs 0.24 [0.10-0.90] ng/mL) nor diagnostically useful (area under the receiver operating characteristic curve, 0.56 [95% confidence interval, .51-.60]).

Indexed as

coinfectionCOVID-19procalcitoninSARS-CoV-2

Identifiers

PMID35531376
PMCPMC9070482
OpenAlexW4229072421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.