ArticleNature aging2021
Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology.
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Article in Nature aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers.
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127citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
What it found
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Who cites it
127 citing papers in PubMed, 162 citations in OpenAlex.
- Harnessing the NKG2D immune surveillance pathway using engineered T-cells for the treatment of human disease.Human vaccines & immunotherapeutics · 2026Review
- A compendium of circulating biomarkers of senescence in humans: Insights on mechanistic impact across health domains and modulation by therapeutic interventions.Ageing research reviews · 2026Review
- Review
- Rethinking Senescence Hallmarks in the Brain: Lessons From Peripheral Tissues and Challenges in Defining Neuronal Senescence.Aging cell · 2026Review
- Senescence Markers and Associated Transcriptomic Changes Are Expressed at Early Stages of Alzheimer's Neuropathology but Are Not Independently Related to Dementia.International journal of molecular sciences · 2026Article
- Research progress of traditional Chinese medicine interventions for aging-related nervous system diseases.Biogerontology · 2026Review
- Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer's disease.Science (New York, N.Y.) · 2026Article
- APOE4 disrupts the central dogma by arresting neuronal proteome dynamics.bioRxiv : the preprint server for biology · 2026Article
- Epigenetic dynamics of cellular senescence: From mechanistic insights to precision senotherapy.Chinese medical journal · 2026Review
- Microglial checkpoint collapse in Alzheimer's disease: a tri-axial framework for biomarker-informed neuroimmune therapy.Journal of neuroinflammation · 2026Review
- Review
- Repurposing niclosamide to mitigate inflammaging: a review of multi-target mechanisms in cellular senescence and age-related decline.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Investigating the Causal Links between the Aging Process and Alzheimer's Disease Pathogenesis.International journal of stem cells · 2026Review
- Region-specific transcriptional signatures of brain aging in the absence of neuropathology at the single-cell level.npj aging · 2026Article
- Senolytic treatment with dasatinib and quercetin selectively improves cardiac autonomic balance in obesity.GeroScience · 2026Article
- The role of lipid metabolism in neuronal senescence.FEBS open bio · 2026Review
- Single-nucleus brain transcriptomics reveals microglia dysfunction in multiple system atrophy.Nature communications · 2026Article
- DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons.bioRxiv : the preprint server for biology · 2026Article
- Cell Type-Specific Expression of p16, p21, and p53 Reveals Age-Dependent Glial Senescence in the AppAging cell · 2026Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 1 country.
Shiva Kazempour DehkordiGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, 7400 Merton Minter, San Antonio, TX, 78229, USA.
Jamie WalkerGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, 7400 Merton Minter, San Antonio, TX, 78229, USA.
Eric SahDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Emma BennettDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Farzaneh AtrianDepartment of Cell Systems and Anatomy, University of Texas Health San Antonio, San Antonio, Texas, USA.
Bess FrostGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, 7400 Merton Minter, San Antonio, TX, 78229, USA.
Benjamin WoostDepartment of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Rachel E BennettDepartment of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Timothy C OrrDepartment of Healthcare Innovations, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Yingyue ZhouDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Prabhakar S AndheyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Peter H SudmantDepartment of Integrative Biology, University of California Berkeley, Berkeley, CA, 94720, USA.
Peng XuDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Minghui WangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Bin ZhangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Habil ZareGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, 7400 Merton Minter, San Antonio, TX, 78229, USA.ORCID 0000-0001-5902-6238
Miranda E OrrDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-0418-2724
The University of Texas Health Science Center at San Antonio · USWake Forest University · USIcahn School of Medicine at Mount Sinai · USWashington University in St. Louis · USHarvard University · USInstitute for Neurodegenerative Disorders · USUniversity of California, Berkeley · US
Funding
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MResearch Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5MIntegrative Network Biology Approaches to Identify, Characterize and Validate Molecular Subtypes in Alzheimer's DiseaseU01AG046170 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, GANDY, SAMUEL E. · 2013 to 2022
$26.0MRush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7MSouth Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Mohamad Habes · 2021 to 2026
$24.0MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MSan Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Adam Salmon · 2015 to 2026
$14.1MMulti-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7MTRAINING GRANT ON THE BIOLOGY OF AGINGT32AG021890 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Erzsebet Kokovay, JAMES FLOYD NELSON · 2003 to 2026
$11.4MIntegrative Network Modeling of Cognitive Resilience to Alzheimer's DiseaseR01AG057907 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, HAROUTUNIAN, VAHRAM · 2017 to 2021
$6.3MSYSTEMATIC DRUG REPURPOSING TARGETING IMMUNE ACTIVATION NETWORKS IN ALZHEIMER'S DISEASE (AD)RF1AG059319 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EHRLICH, MICHELLE E, GANDY, SAMUEL E. · 2018 to 2018
$4.2MBLRD VA IK2 BX003804NIA NIH HHS K99 AG061259NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG044271NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072975NIA NIH HHS R00 AG061259NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG057896NIA NIH HHS R01 AG057907NIA NIH HHS R01 AG068293NIA NIH HHS R21 AG059176NIA NIH HHS RF1 AG051485NIA NIH HHS RF1 AG057440NIA NIH HHS RF1 AG057473NIA NIH HHS RF1 AG059082NIA NIH HHS RF1 AG059319NIA NIH HHS T32 AG021890NIA NIH HHS U01 AG046170NIA NIH HHS U01 AG052409NIA NIH HHS U01 AG061356NINDS NIH HHS RF1 NS112391
Abstract
Senescent cells contribute to pathology and dysfunction in animal models
Indexed as
Alzheimer DiseaseNeuronsAnimalsBrainCellular SenescenceCyclin-Dependent Kinase Inhibitor p19HumansCDKN2D protein, humanCyclin-Dependent Kinase Inhibitor p19
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