Evidence map›Paper›PMID 35531281›Full record

ArticleFrontiers in microbiology2022

Novel Viral DNA Polymerases From Metagenomes Suggest Genomic Sources of Strand-Displacing Biochemical Phenotypes.

Rachel A Keown, Jacob T Dums, Phillip J Brumm, Joyanne MacDonald, David A Mead, Barbra D Ferrell, Ryan M Moore, Amelia O Harrison, Shawn W Polson, K Eric Wommack

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Jumping DNA polymerases in bacteriophages.bioRxiv : the preprint server for biology · 2024
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Rachel A KeownDepartment of Biological Sciences, College of Arts and Sciences, University of Delaware, Newark, DE, United States.
Jacob T DumsBiotechnology Program, North Carolina State University, Raleigh, NC, United States.
Phillip J BrummVarigen Biosciences Corporation, Middleton, WI, United States.
Joyanne MacDonaldVarigen Biosciences Corporation, Middleton, WI, United States.
David A MeadVarigen Biosciences Corporation, Middleton, WI, United States.
Barbra D FerrellDepartment of Plant and Soil Sciences, College of Agriculture and Natural Resources, University of Delaware, Newark, DE, United States.
Ryan M MooreCenter for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, United States.
Amelia O HarrisonCenter for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, United States.
Shawn W PolsonCenter for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, United States.
K Eric WommackDepartment of Plant and Soil Sciences, College of Agriculture and Natural Resources, University of Delaware, Newark, DE, United States.
University of Delaware · USVarigen Biosciences (United States) · USNorth Carolina State University · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Anjana Narayan Bhat · 2012 to 2026
$67.2M
NIGMS NIH HHS P20 GM103446
6 · The paper itself

Abstract

Viruses are the most abundant and diverse biological entities on the planet and constitute a significant proportion of Earth's genetic diversity. Most of this diversity is not represented by isolated viral-host systems and has only been observed through sequencing of viral metagenomes (viromes) from environmental samples. Viromes provide snapshots of viral genetic potential, and a wealth of information on viral community ecology. These data also provide opportunities for exploring the biochemistry of novel viral enzymes. The

Indexed as

bacteriophageenzymologyfunctional metagenomicsgenome replicationstrand displacementvirus

Identifiers

PMID35531281
PMCPMC9069017
OpenAlexW4224230002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.