Evidence map›Paper›PMID 35530972›Full record

ArticleInternational journal of nanomedicine2022

Self-Assembly Catalase Nanocomplex Conveyed by Bacterial Vesicles for Oxygenated Photodynamic Therapy and Tumor Immunotherapy.

Jiayu Zhang, Zinan Li, Ling Liu, Longyun Li, Lu Zhang, Yongkun Wang, Jia Zhao

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. MnOPharmaceutics · 2026
    Article
  4. Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
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  10. Article
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  12. Targeting catalase in cancer.Redox biology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiayu Zhang *Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Zinan Li *Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Ling LiuDepartment of Pediatrics, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Longyun LiDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Lu ZhangDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Yongkun WangDepartment of Orthopedic, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Jia ZhaoDepartment of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People's Republic of China.
Jilin University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Photodynamic therapy (PDT) is an effective therapeutic modality that has been extensively studied in treatment of various cancers. However, issues with inadequate oxygen (O Methods: Firstly, the self-assembly nanocomplex (CAT-Ce6), which is composed of hydrophilic catalase and hydrophobic photosensitizer Chlorin e6 (Ce6), was fabricated to support oxygenated PDT. Secondly, for supplying PDT with enhanced antitumoral immunity, CAT-Ce6 was coated with PD-L1 antibody modified-attenuated Results: The self-assembly nanocomplex (CAT-Ce6) generated sufficient O Conclusion: The resultant CAT-Ce6@OMV-aPDL1 displays excellent efficacy of PDT and immunotherapy to achieve antitumor effects, which provides a new avenue for combinatorial therapy against various cancers.

Indexed as

PhotochemotherapyPorphyrinsBacteriaCatalaseCell Line, TumorHumansHypoxiaImmunotherapyOxygenPhotosensitizing AgentsCatalaseOxygenPhotosensitizing AgentsPorphyrinsanti-tumor immune responseimmune memory effectlong term hypoxia relievingoxygenated photodynamic therapy

Identifiers

PMID35530972
PMCPMC9076005
OpenAlexW4225264148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.