Evidence map›Paper›PMID 35530959›Full record

ArticleAnnals of translational medicine2022

Downregulated ALKBH5 contributes to myocardial ischemia/reperfusion injury by increasing m

Jiaxin Li, Jieshan Chen, Mingyi Zhao, Zhetao Li, Nanbo Liu, Heng Fang, Miaoxian Fang, Ping Zhu, Liming Lei, Chunbo Chen

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. A comprehensive review of m6 A methylation in coronary heart disease.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  4. Review
  5. Article
  6. The role of RNA m6A demethylase ALKBH5 in the mechanisms of fibrosis.Frontiers in cell and developmental biology · 2024
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jiaxin Li *The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Jieshan Chen *Department of Emergency, Maoming People's Hospital, Maoming, China.
Mingyi Zhao *Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Zhetao LiThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Nanbo LiuDepartment of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Heng FangThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Miaoxian FangDepartment of Intensive Care Unit of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Ping ZhuThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Liming Lei *Department of Intensive Care Unit of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Chunbo Chen *The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Guangdong Academy of Medical Sciences · CNSouthern Medical University · CNGuangdong Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The modification of N Methods: A mouse model of MIRI and a cell model of oxygen-glucose deprivation/reperfusion (OGD/R) HL-1 cells were employed. In an Results: Our results showed that RNA m Conclusions: This study demonstrated that the downregulated

Indexed as

AlkB homolog 5 (ALKBH5)myocardial ischemia/reperfusion injury (MIRI)N6-methyladenosine modification (m6A modification)

Identifiers

PMID35530959
PMCPMC9073777
OpenAlexW4229440173

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.