Evidence map›Paper›PMID 35530816›Full record

ArticleCell genomics2022

Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed.

Margaret A Taub, Matthew P Conomos, Rebecca Keener, Kruthika R Iyer, Joshua S Weinstock, Lisa R Yanek, John Lane, Tyne W Miller-Fleming, Jennifer A Brody, Laura M Raffield and 141 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell genomics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. Article
  5. How telomere attrition protects against cancer.Nature reviews. Genetics · 2026
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  16. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

151 authors.

Margaret A TaubDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.
Matthew P ConomosDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Rebecca KeenerDepartment of Biomedical Engineering, Johns Hopkins Whiting School of Engineering, Baltimore, MD, USA.
Kruthika R IyerDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.
Joshua S WeinstockDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Lisa R YanekGeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore MD USA.
John LaneDepartment of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN, USA.
Tyne W Miller-FlemingDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Caitlin P McHughDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Deepti JainDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Stephanie M GogartenDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Cecelia A LaurieDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Ali KeramatiDepartment of Cardiology, Johns Hopkins School of Medicine, Baltimore MD USA.
Marios ArvanitisDepartment of Medicine, Division of Cardiology, Johns Hopkins School of Medicine, Baltimore MD USA.
Albert V SmithDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Benjamin HeavnerDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Lucas BarwickLTRC Data Coordinating Center, The Emmes Company, LLC, Rockville, MD, USA.
Lewis C BeckerGeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore MD USA.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
John BlangeroDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Eugene R BleeckerDepartment of Medicine, Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ, USA.
Esteban G BurchardDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Juan C CeledónDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Yen Pei C ChangDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Brian CusterVitalant Research Institute, San Francisco, CA, USA.
Dawood DarbarDivision of Cardiology, University of Illinois at Chicago, Chicago, IL, USA.
Lisa de las FuentesCardiovascular Division, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Dawn L DeMeoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Barry I FreedmanDepartment of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Melanie E GarrettDepartment of Medicine and Duke Comprehensive Sickle Cell Center, Duke University Medical Center, Durham, NC, USA.
Mark T GladwinDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Susan R HeckbertCardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.
Bertha A HidalgoDepartment of Epidemiology, University of Alabama Birmingham, Birmingham, AL, USA.
Marguerite R IrvinDepartment of Epidemiology, University of Alabama Birmingham, Birmingham, AL, USA.
Talat IslamDivision of Environmental Health, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
W Craig JohnsonDepartment of Biostatistics, Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA, USA.
Stefan KaabDepartment of Medicine I, University Hospital Munich, Ludwig-Maximilian's University, Munich, Germany.
Lenore LaunerLaboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Jiwon LeeDepartment of Medicine, Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
Simin LiuDepartment of Epidemiology and Brown Center for Global Cardiometabolic Health, Brown University, Providence, RI, USA.
Arden MoscatiThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Patricia A PeyserDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Nicholas RafaelsDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Christine SeidmanGenetics, Harvard Medical School, Boston, MA, USA.
Daniel E WeeksDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Fayun WenCenter for Sickle Cell Disease and Department of Medicine, College of Medicine, Howard University, Washington, DC 20059 USA.
Marsha M WheelerDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
L Keoki WilliamsCenter for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
Ivana V YangDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Wei ZhaoDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Stella AslibekyanDepartment of Epidemiology, University of Alabama Birmingham, Birmingham, AL, USA.
Paul L AuerZilber School of Public Health, University of Wisconsin Milwaukee, Milwaukee WI, USA.
Donald W BowdenDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Brian E CadeDivision of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Zhanghua ChenDivision of Environmental Health, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Michael H ChoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Joanne E CurranDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Michelle DayaDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Ranjan DekaDepartment of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
Celeste EngDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Tasha E FingerlinCenter for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Lifang HouDepartment of Preventive Medicine, Northwestern University, Chicago, IL, USA.
Shih-Jen HwangPopulation Sciences Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institute of Health, Bethesda, MD, USA.
Jill M JohnsenBloodworks Northwest, Research Institute, Seattle, WA, USA.
Eimear E KennyCenter for Genomic Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Albert M LevinDepartment of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA.
Chunyu LiuThe National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.
Ryan L MinsterDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Take NaseriMinistry of Health, Government of Samoa, Apia, Samoa.
Mehdi NouraieDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Muagututi'a Sefuiva ReupenaLutia i Puava ae Mapu i Fagalele, Apia, Samoa.
Ester C SabinoInstituto de Medicina Tropical da Faculdade de Medicina da Uiversidade de Sao Paulo, Sao Paulo, Brazil.
Jennifer A SmithDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Nicholas L SmithCardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.
Jessica Lasky SuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
James G TaylorCenter for Sickle Cell Disease and Department of Medicine, College of Medicine, Howard University, Washington, DC 20059 USA.
Marilyn J TelenDepartment of Medicine and Duke Comprehensive Sickle Cell Center, Duke University Medical Center, Durham, NC, USA.
Hemant K TiwariDepartment of Biostatistics, University of Alabama Birmingham, Birmingham, AL, USA.
Russell P TracyDepartments of Pathology & Laboratory Medicine and Biochemistry, Larrner College of Medicine, University of Vermont, Colchester, VT, USA.
Marquitta J WhiteDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Yingze ZhangDepartment of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Scott T WeissChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Ramachandran S VasanDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Moritz F SinnerDepartment of Medicine I, University Hospital Munich, Ludwig-Maximilian's University, Munich, Germany.
Edwin K SilvermanChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
M Benjamin ShoemakerDepartments of Medicine, Pharmacology, and Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
Wayne H-H SheuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Frank SciurbaDivision of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
David A SchwartzDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Daniel RodenDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
Susan RedlineDivision of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Benjamin A RabyDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
Juan M PeraltaDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Sergei NekhaiCenter for Sickle Cell Disease and Department of Medicine, College of Medicine, Howard University, Washington, DC 20059 USA.
Courtney G MontgomeryGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.
Braxton D MitchellDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Deborah A MeyersDepartment of Medicine, Division of Genetics, Genomics and Precision Medicine, University of Arizona, Tucson, AZ, USA.
Stephen T McGarveyDepartment of Epidemiology & International Health Institute, School of Public Health, Brown University, Providence, USA.
NHLBI CARE Network
Angel Cy MakDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Ruth Jf LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rajesh KumarDivision of Allergy and Clinical Immunology, The Ann and Robert H. Lurie Children's Hospital of Chicago, and Department of Pediatrics Northwestern University, Chicago, IL, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Htutchinson Cancer Research Center, Seattle WA, USA.
Barbara A KonkleBloodworks Northwest, Research Institute, Seattle, WA, USA.
Shannon KellyVitalant Research Institute, San Francisco, CA, USA.
Sharon Lr KardiaDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Robert KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Jiang HeDepartment of Medicine, Tulane University School of Medicine, New Orleans, LA, USA.
Hongsheng GuiCenter for Individualized and Genomic Medicine Research (CIGMA), Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA.
Frank D GillilandDivision of Environmental Health, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Bruce D GelbMindich Child Health and Development Institute, Departments of Pediatrics and Genetics & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Patrick T EllinorCardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA.
Mariza de AndradeDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN,USA.
Adolfo CorreaJackson Heart Study and Departments of Medicine and Population Health Science, Jackson, MS, USA.
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Kathleen C BarnesDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Allison E Ashley-KochDepartment of Medicine and Duke Comprehensive Sickle Cell Center, Duke University Medical Center, Durham, NC, USA.
Donna K ArnettCollege of Public Health, University of Kentucky, Lexington, KY, USA.
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
TOPMed Hematology and Hemostasis Working Group
TOPMed Structural Variation Working Group
Cathy C LaurieDepartment of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA.
Goncalo AbecasisDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MI, USA.
Stephen S RichCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Daniel LevyThe National Heart, Lung, and Blood Institute, Boston University's Framingham Heart Study, Framingham, MA, USA.
Ingo RuczinskiDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA.
Abraham AvivCenter of Human Development and Aging, Rutgers, New Jersey Medical School, Newark, NJ, USA.
Thomas W BlackwellDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Timothy ThorntonDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Jeff O'ConnellDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Nancy J CoxVanderbilt Genetics Institute and Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
James A PerryDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Mary ArmaniosDepartment of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Alexis BattleDepartment of Biomedical Engineering, Johns Hopkins Whiting School of Engineering, Baltimore, MD, USA.
Nathan PankratzDepartment of Laboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN, USA.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Rasika A MathiasGeneSTAR Research Program, Department of Medicine, Johns Hopkins School of Medicine, Baltimore MD USA.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Center for Common Disease GeneticsUM1HG008895 · NHGRI · BROAD INSTITUTE, INC. · PI DALY, MARK JOSEPH, GABRIEL, STACEY · 2016 to 2020
$111.2M
NHLBI Data Stage Coordinating CenterOT3HL147154 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ashok Kumar Krishnamurthy · 2018 to 2026
$98.9M
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUH3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2018 to 2026
$64.8M
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Urban Air Pollution and Children's Respiratory HealthP01ES011627 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GILLILAND, FRANK D. · 2002 to 2011
$30.2M
University of Maryland Claude D. Pepper Older Americans Independence Center (UM-OAIC)P30AG028747 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Stephen L. Seliger · 2006 to 2026
$28.9M
PEDIGREE ANALYSIS OF LIPOPROTEIN PHENOTYPESP01HL045522 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ALMASY, LAURA A. · 1991 to 2012
$27.6M
The Integration of Trans-omics for Precision Medicine (TOPMED) and Other Heart, Lung, Blood and Sleep (HLBS) Data Sets with the Data CommonsOT3HL142481 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI GROSSMAN, ROBERT L., PATEN, BENEDICT · 2017 to 2020
$24.9M
BLRD VA I01 BX005295NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS S10 RR025141NCRR NIH HHS UL1 RR024975NHGRI NIH HHS T32 HG000040NHGRI NIH HHS U01 HG004798NHGRI NIH HHS U01 HG006378NHGRI NIH HHS UM1 HG008895NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500014CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K01 HL135405NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS OT3 HL142478NHLBI NIH HHS OT3 HL142479NHLBI NIH HHS OT3 HL142480NHLBI NIH HHS OT3 HL142481NHLBI NIH HHS OT3 HL147154NHLBI NIH HHS P01 HL045522NHLBI NIH HHS R01 HL046380NHLBI NIH HHS R01 HL055673NHLBI NIH HHS R01 HL056177NHLBI NIH HHS R01 HL066216NHLBI NIH HHS R01 HL067348NHLBI NIH HHS R01 HL068959NHLBI NIH HHS R01 HL068986NHLBI NIH HHS R01 HL069234NHLBI NIH HHS R01 HL071051NHLBI NIH HHS R01 HL071205NHLBI NIH HHS R01 HL071250NHLBI NIH HHS R01 HL071258NHLBI NIH HHS R01 HL071259NHLBI NIH HHS R01 HL073410NHLBI NIH HHS R01 HL079915NHLBI NIH HHS R01 HL080083NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL087263NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL087698NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL090682NHLBI NIH HHS R01 HL091889NHLBI NIH HHS R01 HL092217NHLBI NIH HHS R01 HL092301NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL093093NHLBI NIH HHS R01 HL095080NHLBI NIH HHS R01 HL097163NHLBI NIH HHS R01 HL104135NHLBI NIH HHS R01 HL104608NHLBI NIH HHS R01 HL111249NHLBI NIH HHS R01 HL112064NHLBI NIH HHS R01 HL113264NHLBI NIH HHS R01 HL113323NHLBI NIH HHS R01 HL113326NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL118267NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL121007NHLBI NIH HHS R01 HL132523NHLBI NIH HHS R01 HL133040NHLBI NIH HHS R01 HL133221NHLBI NIH HHS R01 HL141845NHLBI NIH HHS R01 HL143818NHLBI NIH HHS R01 HL157635NHLBI NIH HHS R03 HL154284NHLBI NIH HHS R35 HL135818NHLBI NIH HHS R37 HL066289NHLBI NIH HHS RC1 HL099355NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL054464NHLBI NIH HHS U01 HL054472NHLBI NIH HHS U01 HL054481NHLBI NIH HHS U01 HL054527NHLBI NIH HHS U01 HL065962NHLBI NIH HHS U01 HL072496NHLBI NIH HHS U01 HL072507NHLBI NIH HHS U01 HL072518NHLBI NIH HHS U01 HL072524NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL117721NHLBI NIH HHS U01 HL130045NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U01 HL157004NHLBI NIH HHS U10 HL054472NHLBI NIH HHS U10 HL064287NHLBI NIH HHS U10 HL064288NHLBI NIH HHS U10 HL064295NHLBI NIH HHS U10 HL064305NHLBI NIH HHS U10 HL064307NHLBI NIH HHS U10 HL064313NHLBI NIH HHS U10 HL098112NHLBI NIH HHS U10 HL109164NHLBI NIH HHS U19 HL065962NHLBI NIH HHS UG1 HL139054NHLBI NIH HHS UH3 HL151865NHLBI NIH HHS UM1 HL098123NHLBI NIH HHS UM1 HL098147NHLBI NIH HHS UM1 HL098162NHLBI NIH HHS UM1 HL128711NHLBI NIH HHS UM1 HL128761NIAID NIH HHS U01 AI126614NIAMS NIH HHS R01 AR048797NIA NIH HHS P30 AG028747NIA NIH HHS R01 AG058921NICHD NIH HHS R01 HD074711NIDDK NIH HHS R01 DK071891NIDDK NIH HHS R01 DK113003NIEHS NIH HHS P01 ES011627NIEHS NIH HHS R01 ES021801NIGMS NIH HHS P50 GM115305NIGMS NIH HHS R25 GM062459NIGMS NIH HHS RC2 GM092618NIH HHS S10 OD017985NIH HHS UG3 OD023282NIH HHS UH3 OD023282NINDS NIH HHS R01 NS032830NINDS NIH HHS R01 NS058700
6 · The paper itself

Abstract

Genetic studies on telomere length are important for understanding age-related diseases. Prior GWAS for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally-diverse individuals (European, African, Asian and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n=109,122 individuals. We identified 59 sentinel variants (p-value <5×10

Identifiers

PMID35530816
PMCPMC9075703

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