Evidence map›Paper›PMID 35530662›Full record

ArticleTobacco regulatory science2020

Analysis of Multiple Biomarkers Using Structural Equation Modeling.

Wenhao Cao, Stephen S Hecht, Sharon E Murphy, Haitao Chu, Neal L Benowitz, Eric C Donny, Dorothy K Hatsukami, Xianghua Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tobacco regulatory science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenhao CaoWenhao Cao, Master of Science Student, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Stephen S. Hecht, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Sharon E. Murphy, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Haitao Chu, Professor, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Neal L. Benowitz, Professor, University of California, Department of Medicine, San Francisco, CA. Eric C. Donny, Professor, Wake Forest School of Medicine, Department of Physiology and Pharmacology, Winston-Salem, NC. Dorothy K. Hatsukami, Professor, Masonic Cancer Center and Department of Psychiatry, University of Minnesota, Minneapolis, MN. Xianghua Luo, Associate Professor, Division of Biostatistics School of Public Health and Masonic Cancer Center, University of Minnesota, Minneapolis, MN.
Stephen S HechtWenhao Cao, Master of Science Student, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Stephen S. Hecht, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Sharon E. Murphy, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Haitao Chu, Professor, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Neal L. Benowitz, Professor, University of California, Department of Medicine, San Francisco, CA. Eric C. Donny, Professor, Wake Forest School of Medicine, Department of Physiology and Pharmacology, Winston-Salem, NC. Dorothy K. Hatsukami, Professor, Masonic Cancer Center and Department of Psychiatry, University of Minnesota, Minneapolis, MN. Xianghua Luo, Associate Professor, Division of Biostatistics School of Public Health and Masonic Cancer Center, University of Minnesota, Minneapolis, MN.
Sharon E MurphyWenhao Cao, Master of Science Student, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Stephen S. Hecht, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Sharon E. Murphy, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Haitao Chu, Professor, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Neal L. Benowitz, Professor, University of California, Department of Medicine, San Francisco, CA. Eric C. Donny, Professor, Wake Forest School of Medicine, Department of Physiology and Pharmacology, Winston-Salem, NC. Dorothy K. Hatsukami, Professor, Masonic Cancer Center and Department of Psychiatry, University of Minnesota, Minneapolis, MN. Xianghua Luo, Associate Professor, Division of Biostatistics School of Public Health and Masonic Cancer Center, University of Minnesota, Minneapolis, MN.
Haitao ChuWenhao Cao, Master of Science Student, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Stephen S. Hecht, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Sharon E. Murphy, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Haitao Chu, Professor, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Neal L. Benowitz, Professor, University of California, Department of Medicine, San Francisco, CA. Eric C. Donny, Professor, Wake Forest School of Medicine, Department of Physiology and Pharmacology, Winston-Salem, NC. Dorothy K. Hatsukami, Professor, Masonic Cancer Center and Department of Psychiatry, University of Minnesota, Minneapolis, MN. Xianghua Luo, Associate Professor, Division of Biostatistics School of Public Health and Masonic Cancer Center, University of Minnesota, Minneapolis, MN.
Neal L BenowitzWenhao Cao, Master of Science Student, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Stephen S. Hecht, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Sharon E. Murphy, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Haitao Chu, Professor, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Neal L. Benowitz, Professor, University of California, Department of Medicine, San Francisco, CA. Eric C. Donny, Professor, Wake Forest School of Medicine, Department of Physiology and Pharmacology, Winston-Salem, NC. Dorothy K. Hatsukami, Professor, Masonic Cancer Center and Department of Psychiatry, University of Minnesota, Minneapolis, MN. Xianghua Luo, Associate Professor, Division of Biostatistics School of Public Health and Masonic Cancer Center, University of Minnesota, Minneapolis, MN.
Eric C DonnyWenhao Cao, Master of Science Student, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Stephen S. Hecht, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Sharon E. Murphy, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Haitao Chu, Professor, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Neal L. Benowitz, Professor, University of California, Department of Medicine, San Francisco, CA. Eric C. Donny, Professor, Wake Forest School of Medicine, Department of Physiology and Pharmacology, Winston-Salem, NC. Dorothy K. Hatsukami, Professor, Masonic Cancer Center and Department of Psychiatry, University of Minnesota, Minneapolis, MN. Xianghua Luo, Associate Professor, Division of Biostatistics School of Public Health and Masonic Cancer Center, University of Minnesota, Minneapolis, MN.
Dorothy K HatsukamiWenhao Cao, Master of Science Student, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Stephen S. Hecht, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Sharon E. Murphy, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Haitao Chu, Professor, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Neal L. Benowitz, Professor, University of California, Department of Medicine, San Francisco, CA. Eric C. Donny, Professor, Wake Forest School of Medicine, Department of Physiology and Pharmacology, Winston-Salem, NC. Dorothy K. Hatsukami, Professor, Masonic Cancer Center and Department of Psychiatry, University of Minnesota, Minneapolis, MN. Xianghua Luo, Associate Professor, Division of Biostatistics School of Public Health and Masonic Cancer Center, University of Minnesota, Minneapolis, MN.
Xianghua LuoWenhao Cao, Master of Science Student, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Stephen S. Hecht, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Sharon E. Murphy, Professor, Masonic Cancer Center, University of Minnesota, Minneapolis, MN. Haitao Chu, Professor, Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN. Neal L. Benowitz, Professor, University of California, Department of Medicine, San Francisco, CA. Eric C. Donny, Professor, Wake Forest School of Medicine, Department of Physiology and Pharmacology, Winston-Salem, NC. Dorothy K. Hatsukami, Professor, Masonic Cancer Center and Department of Psychiatry, University of Minnesota, Minneapolis, MN. Xianghua Luo, Associate Professor, Division of Biostatistics School of Public Health and Masonic Cancer Center, University of Minnesota, Minneapolis, MN.

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HEATHER Hammond NELSON · 1998 to 2026
$100.4M
VERY LOW NICOTINE CIGARETTES IN SMOKERS WITH SCHIZOPHRENIAU54DA031659 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DONNY, ERIC CHRISTIAN · 2011 to 2022
$64.7M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
NCATS NIH HHS UL1 TR000114NCI NIH HHS P30 CA077598NIDA NIH HHS U54 DA031659
6 · The paper itself

Abstract

Objectives: When examining the relationship between smoking intensity and toxicant exposure biomarkers in an effort to understand the potential risk for smoking-related disease, individual biomarkers may not be strongly associated with smoking intensity because of the inherent variability in biomarkers. Structural equation modeling (SEM) offers a powerful solution by modeling the relationship between smoking intensity and multiple biomarkers through a latent variable. Methods: Baseline data from a randomized trial (N = 1250) were used to estimate the relationship between smoking intensity and a latent toxicant exposure variable summarizing five volatile organic compound biomarkers. Two variables of smoking intensity were analyzed: the self-report cigarettes smoked per day and total nicotine equivalents in urine. SEM was compared with linear regression with each biomarker analyzed individually or with the sum score of the five biomarkers. Results: SEM models showed strong relationships between smoking intensity and the latent toxicant exposure variable, and the relationship was stronger than its counterparts in linear regression with each biomarker analyzed separately or with the sum score. Conclusions: SEM is a powerful multivariate statistical method for studying multiple biomarkers assessing the same class of harmful constituents. This method could be used to evaluate exposure from different combusted tobacco products.

Indexed as

biological marker (biomarker)cigarette smokelatent variablemultivariate statistical methodstructural equation modelling

Identifiers

PMID35530662
PMCPMC9075702

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.