Evidence map›Paper›PMID 35530654›Full record

ReviewCancer diagnosis & prognosis

Impact of Hippocampal Avoidance - Prophylactic Cranial Irradiation in Small Cell Lung Cancer Patients.

Emmanouil Maragkoudakis, Vasileios Kouloulias, Maria Grenzelia, Andromachi Kougioumtzopoulou, Anna Zygogianni, Vasileios Ramfidis, Andrianni Charpidou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emmanouil MaragkoudakisNational and Kapodistrian University of Athens, 2nd Radiology Department, Radiotherapy Unit, Attikon University Hospital, Athens, Greece.
Vasileios KoulouliasNational and Kapodistrian University of Athens, 2nd Radiology Department, Radiotherapy Unit, Attikon University Hospital, Athens, Greece.
Maria GrenzeliaNational and Kapodistrian University of Athens, 1st Radiology Department, Radiotherapy Unit, Aretaieion University Hospital, Athens, Greece.
Andromachi KougioumtzopoulouNational and Kapodistrian University of Athens, 2nd Radiology Department, Radiotherapy Unit, Attikon University Hospital, Athens, Greece.
Anna ZygogianniNational and Kapodistrian University of Athens, 1st Radiology Department, Radiotherapy Unit, Aretaieion University Hospital, Athens, Greece.
Vasileios RamfidisSchool of Medicine, National & Kapodistrian University, 3rd Department of Medicine, Sotiria General Hospital, Athens, Greece.
Andrianni CharpidouSchool of Medicine, National & Kapodistrian University, 3rd Department of Medicine, Sotiria General Hospital, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimProphylactic cranial irradiation (PCI) is a well-established treatment of small cell lung cancer (SCLC) patients following response to initial chemoradiotherapy. The benefit of PCI does, however, come at the cost of cognitive decline. This has been attributed to radiation-induced toxicity at the hippocampus, a crucial anatomic area for cognition. Modern radiotherapy techniques allow dose reduction at the hippocampal region. In this review, the safety profile, effect on cognition, and changes on brain imaging modalities of hippocampal avoidance-PCI (HA-PCI) will be presented, aiming to identify a potential clinical rationale for SCLC patients. MATERIALS AND

methodsA systematic review of the literature was performed in Pubmed, Cochrane library databases and ClinicalTrials.gov with no past date limitations until 07/01/2022. Principles as outlined in the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement were followed.

resultsEight studies published from 2015 to 2021 were included.

conclusionHA-PCI is safe, yet its effect on neurocognition and imaging remains unclear, as studies have shown contradictory results.

Indexed as

hippocampal avoidanceneurocognitionProphylactic cranial irradiationreviewsmall cell lung cancer

Identifiers

PMID35530654
PMCPMC9066538

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.