ArticleCancer diagnosis & prognosis
Survival Outcomes of Patients With Primary Mediastinal Germ Cell Tumors: A Retrospective Single-institutional Experience.
Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Article
- Anemic retinopathy as the presenting symptom of a mediastinal germ cell tumor.American journal of ophthalmology case reports · 2025Article
- Primary Mediastinal Germ Cell Tumor With Bone Marrow Infiltration: A Case Report and Literature Review.Cancer reports (Hoboken, N.J.) · 2025Review
- Maediastinal germ cell tumors: analysis using hospital-based cancer registry data in Japan.International journal of clinical oncology · 2024Article
- Pure mediastinal seminoma about a case report.Radiology case reports · 2023Article
- [Development of A Nomogram for Predicting Survival of Patients with Primary Mediastinal Germ Cell Tumor Based on SEER Database].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimPrimary mediastinal non-seminomatous germ cell tumors (PMNSGCTs) are occasionally complicated by a hematologic malignancy, as with somatic-type malignant tumors called germ cell tumors with somatic-type malignancy (GCTSTM) and are known to have a poor prognosis. PATIENTS AND
methodsData obtained between September 1997 and February 2020 for patients with mediastinal germ cell tumor at our institution were retrospectively analyzed. Key outcome measures included survival rates and the clinical features of non-seminoma cases.
resultsOf 16 patients, 9 had pure seminoma, and 7 had non-seminoma. At the median follow-up of 56.2 months, the 5-year survival rate was significantly higher in patients with seminoma (100%) than in those with non-seminoma (37%) (log-rank test, p=0.0153). Regarding PMNSGCT, two patients evolved into GCTSTM and three had concomitant hematological malignancies.
conclusionPatients with PMNSGCTs, GCTSTM complications, and hematologic malignancies showed poor survival, suggesting the need for the development of treatment strategies.
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